DAF-FM
DAF-FM structure
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Common Name | DAF-FM | ||
|---|---|---|---|---|
| CAS Number | 254109-20-1 | Molecular Weight | 412.34300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H14F2N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.
Redox Biol. 1 , 115-24, (2013) JS-K is a nitric oxide (NO)-releasing prodrug of the O (2)-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metabolic acti... |
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Low-level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro.
J. Biophotonics 7(8) , 656-64, (2014) Excitotoxicity describes a pathogenic process whereby death of neurons releases large amounts of the excitatory neurotransmitter glutamate, which then proceeds to activate a set of glutamatergic receptors on neighboring neurons (glutamate, N-methyl-D-aspartat... |
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Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.
Mol. Med. Report. 12 , 937-44, (2015) Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxi... |
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TRPV4 activation mediates flow-induced nitric oxide production in the rat thick ascending limb.
Am. J. Physiol. Renal Physiol. 307(6) , F666-72, (2014) Nitric oxide (NO) regulates renal function. Luminal flow stimulates NO production in the thick ascending limb (TAL). Transient receptor potential vanilloid 4 (TRPV4) is a mechano-sensitive channel activated by luminal flow in different types of cells. We hypo... |
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Melanin protects Paracoccidioides brasiliensis from the effects of antimicrobial photodynamic inhibition and antifungal drugs.
Antimicrob. Agents Chemother. 59 , 4003-11, (2015) Paracoccidioidomycosis (PCM) is a public health concern in Latin America and South America that when not correctly treated can lead to patient death. In this study, the influence of melanin produced by Paracoccidioides spp. on the effects of treatment with an... |
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Astragaloside IV inhibits oxidative stress-induced mitochondrial permeability transition pore opening by inactivating GSK-3β via nitric oxide in H9c2 cardiac cells.
Oxid. Med. Cell. Longev. 2012 , 935738, (2012) This study aimed to investigate whether astragaloside IV modulates the mitochondrial permeability transition pore (mPTP) opening through glycogen synthase kinase 3β (GSK-3β) in H9c2 cells.H9c2 cells were exposed to astragaloside IV for 20 min. GSK-3β (Ser(9))... |
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Triggering apoptotic death of human malignant melanoma a375.s2 cells by bufalin: involvement of caspase cascade-dependent and independent mitochondrial signaling pathways.
Evid. Based. Complement. Alternat. Med. 2012 , 591241, (2012) Bufalin was obtained from the skin and parotid venom glands of toad and has been shown to induce cytotoxic effects in various types of cancer cell lines, but there is no report to show that whether bufalin affects human skin cancer cells. The aim of this inve... |
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Chronic endurance exercise affects paracrine action of CD31+ and CD34+ cells on endothelial tube formation.
Am. J. Physiol. Heart Circ. Physiol. 309 , H407-20, (2015) We aimed to determine if chronic endurance-exercise habits affected redox status and paracrine function of CD34(+) and CD34(-)/CD31(+) circulating angiogenic cells (CACs). Subjects were healthy, nonsmoking men and women aged 18-35 yr and categorized by chroni... |
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Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines.
PLoS ONE 7 , e30671, (2012) Mammalian spermatozoa are not able to fertilize an egg immediately upon ejaculation. They acquire this ability during their transit through the female genital tract in a process known as capacitation. The mammalian oviduct acts as a functional sperm reservoir... |
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Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase.
Exp. Mol. Med. 44 , 191-201, (2012) Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in vascular functions, including vasorelaxation. We here investigated the pharmacological effect of the natural product syringaresinol on vascular relaxation and eNOS-mediate... |