o,p'-dde
o,p'-dde structure
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Common Name | o,p'-dde | ||
|---|---|---|---|---|
| CAS Number | 3424-82-6 | Molecular Weight | 318.025 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 380.6±37.0 °C at 760 mmHg | |
| Molecular Formula | C14H8Cl4 | Melting Point | 78.32°C | |
| MSDS | N/A | Flash Point | 181.8±23.9 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Organochlorine pesticides and polychlorinated biphenyls in sediments and fish from freshwater cultured fish ponds in different agricultural contexts in north-eastern France.
Ecotoxicol. Environ. Saf. 77 , 35-44, (2012) Organochlorine pesticides (HCB, HCH with α-, β-, and γ isomers, heptachlor, cis-heptachlor epoxyde, trans-heptachlor epoxyde, endosulfan with α- and β isomers, sulfate endosulfan, o,p'-DDT, p,p'-DDT, o,p'-DDE, p,p'-DDE, o,p'-DDD, p,p'-DDD, chlorothalonil, ala... |
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DDT- and DDE-induced disruption of ovarian steroidogenesis in prepubertal porcine ovarian follicles: a possible interaction with the main steroidogenic enzymes and estrogen receptor beta.
J. Physiol. Pharmacol. 58(4) , 873-85, (2007) We evaluated impact of DDT isomers, o, p'- DDT [1, 1-dichloro-2, 2-bis (p, p'-chlorophenyl) ethylene] and p, p'-DDT [1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl) ethane], and their metabolites, o, p'-DDE and p, p'-DDE, on ovarian steroidogenesis. All these com... |
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Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study.
J. Clin. Endocrinol. Metab. 96(6) , 1844-51, (2011) In patients with adrenocortical carcinoma (ACC) mitotane activity has been suggested to depend on plasma levels 14 mg/liter or greater and metabolite formation.The study was performed to confirm the correlation of the currently used mitotane (o,p'DDD) thresho... |
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Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid.
J. Clin. Endocrinol. Metab. 85(8) , 2954-7, (2000) Man-made chemicals that have been shown to modulate endocrine function in animal models, so-called "endocrine disrupters", are suspected to play a role in the development of male reproductive tract abnormalities and neurobehaviroal deficits in children. Howev... |
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Plasma level monitoring of mitotane (o,p'-DDD) and its metabolite (o,p'-DDE) during long-term treatment of Cushing's disease with low doses.
Eur. J. Clin. Pharmacol. 41(3) , 259-61, (1991) Mitotane (o,p'-DDD) can be used for the treatment of various adrenocortical diseases such as Cushing's syndrome, but the usual doses of 6-8 g per day are often associated with severe adverse effects. This paper reports the results of much lower doses of o,p'-... |
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Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up.
J. Exp. Ther. Oncol. 5(2) , 125-32, (2005) Our study aimed at evaluation of the relations between the plasma levels of mitotane (o,p'-DDD) and its metabolites, o,p'-DDA and o,p'-DDE, and the efficacy of Mitotane therapy during a long-term follow-up. Eighteen patients, aged 11 to 70 years, were include... |
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Rapid effects of pesticides on human granulosa-lutein cells.
Reproduction 131(2) , 299-310, (2006) Following our previous demonstration that p,p'-DDE (dichlorodiphenylchloroethylene), at environmentally relevant concentrations, can rapidly increase intracellular calcium [Ca2+]i concentrations in human granulosa-lutein cells, we examined whether other pesti... |
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Reporter cell lines to study the estrogenic effects of xenoestrogens.
Sci. Total Environ. 233(1-3) , 47-56, (1999) In order to characterize the estrogenic activity of chemicals, we established complementary in vitro recombinant receptor-reporter gene assays in stably transfected MCF-7 and HeLa cells. MCF-7 cells which express the endogenous estrogen receptor alpha (ER alp... |
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Effects of o,p'-DDE, heptachlor, and 17beta-estradiol on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I axis in the tilapia, Oreochromis mossambicus.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 149(4) , 507-14, (2009) Effects of two endocrine disruptors, o,p'-DDE and heptachlor, and 17beta-estradiol (E(2)) on vitellogenin (Vg) and the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis were examined in male tilapia. In the first experiment, fish were given 5 week... |
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Short-term exposure of Chinook salmon (Oncoryhnchus tshawytscha) to o,p-DDE or DMSO during early life-history stages causes long-term humoral immunosuppression.
Environ. Health Perspect. 111(13) , 1601-7, (2003) We evaluated the effect of short-term exposures to a xenobiotic chemical during early life-history stages on the long-term immune competence of chinook salmon (Oncoryhnchus tshawytscha). Immersion of chinook salmon eggs in a nominal concentration of o,p-dichl... |