4-Bromo-2-furaldehyde

4-Bromo-2-furaldehyde Structure
4-Bromo-2-furaldehyde structure
Common Name 4-Bromo-2-furaldehyde
CAS Number 21921-76-6 Molecular Weight 174.980
Density 1.7±0.1 g/cm3 Boiling Point 225.0±20.0 °C at 760 mmHg
Molecular Formula C5H3BrO2 Melting Point 54-58 °C
MSDS Chinese USA Flash Point 89.9±21.8 °C
Symbol GHS07
GHS07
Signal Word Warning

C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists.

Bioorg. Med. Chem. Lett. 17 , 3778, (2007)

A novel series of cyclobutenedione centered C(4)-alkyl substituted furanyl analogs was developed as potent CXCR2 and CXCR1 antagonists. Compound 16 exhibits potent inhibitory activities against IL-8 binding to the receptors (CXCR2 Ki=1 nM, IC(50)=1.3 nM; CXCR...