Antimycin A
Antimycin A structure
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Common Name | Antimycin A | ||
|---|---|---|---|---|
| CAS Number | 1397-94-0 | Molecular Weight | 548.62500 | |
| Density | 1.6009 (rough estimate) | Boiling Point | 598.78°C (rough estimate) | |
| Molecular Formula | C28H40N2O9 | Melting Point | 141-142℃ | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
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Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo.
Proc. Natl. Acad. Sci. U. S. A. 111(22) , E2271-80, (2014) The Mediator is a conserved transcriptional coregulator complex required for eukaryotic gene expression. In Caenorhabditis elegans, the Mediator subunit mdt-15 is essential for the expression of genes involved in fatty acid metabolism and ingestion-associated... |
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Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model.
Innate Immunity 16 , 67-79, (2010) Lactoferrin is a non-heme iron-binding glycoprotein, produced by mucosal epithelial cells and granulocytes in most mammalian species. It is involved in regulation of immune responses, possesses anti-oxidant, anti-carcinogenic, anti-inflammatory properties, an... |
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Oleic acid stimulates glucagon-like peptide-1 release from enteroendocrine cells by modulating cell respiration and glycolysis.
Metab. Clin. Exp. 65 , 17-Aug, (2016) Glucagon-like peptide-1 (GLP-1) is a potent satiating and incretin hormone released by enteroendocrine L-cells in response to eating. Dietary fat, in particular monounsaturated fatty acids, such as oleic acid (OA), potently stimulates GLP-1 secretion from L-c... |
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Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency.
EMBO J. 35 , 618-34, (2016) Transcription factor Stat3 directs self-renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine leukemia inhibitory factor (LIF). Stat3 upregulates pivotal transcription factors in the ES cell gene regulatory network to sustain naïve... |
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Ion permeabilities in mouse sperm reveal an external trigger for SLO3-dependent hyperpolarization.
PLoS ONE 8 , e60578, (2013) Unlike most cells of the body which function in an ionic environment controlled within narrow limits, spermatozoa must function in a less controlled external environment. In order to better understand how sperm control their membrane potential in different io... |
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Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress.
PLoS ONE 8 , e55110, (2013) The ability of the opportunistic fungal pathogen Cryptococcus neoformans to resist oxidative stress is one of its most important virulence related traits. To cope with the deleterious effect of cellular damage caused by the oxidative burst inside the macropha... |
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Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes.
Stem Cell Reports 5 , 569-81, (2015) Brown adipocytes (BAs) play important roles in body temperature regulation, energy balance, and carbohydrate and lipid metabolism. Activities of BAs are remarkably diminished in obese and diabetic patients, providing possibilities of transplanting functional ... |
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Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.
Redox Biol. 2 , 1008-15, (2016) Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome c1 (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2). Immp2l mutant mice show inf... |
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Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases.
Sci. Rep. 6 , 29946, (2016) Phosphoribosyl pyrophosphate synthetase-1 (PRPS1) is a key enzyme in nucleotide biosynthesis, and mutations in PRPS1 are found in several human diseases including nonsyndromic sensorineural deafness, Charcot-Marie-Tooth disease-5, and Arts Syndrome. We utiliz... |
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The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex.
PLoS ONE 8(2) , e57312, (2013) Stem cell populations are maintained through self-renewing divisions in which one daughter cell commits to a specific fate while the other retains the multipotent characteristics of its parent. The p53 tumor suppressor, in conjunction with its interacting par... |