probenecid
probenecid structure
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Common Name | probenecid | ||
|---|---|---|---|---|
| CAS Number | 57-66-9 | Molecular Weight | 285.359 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 438.0±47.0 °C at 760 mmHg | |
| Molecular Formula | C13H19NO4S | Melting Point | 194-196°C | |
| MSDS | Chinese USA | Flash Point | 218.7±29.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
PLoS ONE 10 , e0127919, (2015) Extracellular nucleotides, such as ATP, are released from cells in response to various stimuli and act as intercellular signaling molecules through activation of P2 receptors. Exposure to the ultraviolet radiation A (UVA) component of sunlight causes molecula... |
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Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.
Drug Metab. Dispos. 42(9) , 1357-66, (2014) Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity ... |
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TRPA1 agonist activity of probenecid desensitizes channel responses: consequences for screening.
Assay Drug Dev. Technol. 10(6) , 533-41, (2012) The transient receptor potential channel subtype A member 1 (TRPA1) is a nonselective cation channel widely viewed as having therapeutic potential, particularly for pain-related indications. Realization of this potential will require potent, selective modulat... |
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Uricosuric drugs, with special reference to probenecid and sulfinpyrazone.
Adv. Pharmacol. 4 , 91-142, (1966)
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TRPM8 is a neuronal osmosensor that regulates eye blinking in mice.
Nat. Commun. 6 , 7150, (2015) Specific peripheral sensory neurons respond to increases in extracellular osmolality but the mechanism responsible for excitation is unknown. Here we show that small increases in osmolality excite isolated mouse dorsal root ganglion (DRG) and trigeminal gangl... |
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Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1039-52, (2015) The histamine H2 receptor (H2R) is a Gs protein-coupled receptor. Its activation leads to increases in the second messenger adenosine-3',5'-cyclic monophosphate (cAMP). Presently, several systems are established to characterize the pharmacological profile of ... |
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Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.
Toxicol. Sci. 141(1) , 206-17, (2014) Ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) is evoked by diverse pathophysiological conditions and/or surgical procedures. Here, we evaluated the nephropreventive effect of sulfotransferase (SULT) inhibitors, quercetin, and resveratrol, which... |
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Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
ACS Chem. Neurosci. 5(12) , 1221-37, (2014) Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and activation ... |
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Once-daily cefazolin and probenecid for skin and soft tissue infections.
Ann. Pharmacother. 38(3) , 458-63, (2004) To review the pharmacokinetic and clinical evidence for the use of once-daily cefazolin and probenecid in the treatment of skin and soft tissue infections (SSTI).MEDLINE (1966-July 2003), EMBASE (1980-July 2003), and PubMed (1966-July 2003) databases for Engl... |
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Proton pump inhibitors inhibit methotrexate transport by renal basolateral organic anion transporter hOAT3.
Drug Metab. Dispos. 42(12) , 2041-8, (2014) The coadministration of methotrexate (MTX) and proton pump inhibitors (PPIs) can result in a pharmacokinetic interaction that delays MTX elimination and subsequently increases the MTX blood concentrations. Human organic anion transporters (hOATs) are responsi... |