Midazolam
Midazolam structure
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Common Name | Midazolam | ||
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| CAS Number | 59467-70-8 | Molecular Weight | 325.767 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 496.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H13ClD4FN3O4 | Melting Point | 161-164°C | |
| MSDS | N/A | Flash Point | 254.3±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.
Biochem. Pharmacol. 92(4) , 701-11, (2014) The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the pharmacokinetics and metabolic fate of midazolam, a drug kn... |
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Can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?
Clin. Pharmacol. Ther. 95(5) , 489, (2014)
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Response to "can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?": evaluation of CYP3A activity with microdoses of midazolam.
Clin. Pharmacol. Ther. 95(5) , 490-1, (2014)
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Effect of myricetin on cytochrome P450 isoforms CYP1A2, CYP2C9 and CYP3A4 in rats.
Pharmazie 69(4) , 306-10, (2014) Myricetin is one of the main ingredients of Chinese bayberry, which is used as a traditional medicine. The purpose of this study was to find out whether myricetin influences the rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C9 and CYP3A4) by using cocktail p... |
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Effects of icaritin on cytochrome P450 enzymes in rats.
Pharmazie 69(4) , 301-5, (2014) The purpose of this study was to find out whether icaritin influences the effect on rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C9, CYP2E1 and CYP3A4) using cocktail probe drugs in vivo. A cocktail solution at a dose of 5 mL/kg, which contained phenacetin ... |
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Correlation of patient-reported outcomes of sedation and sedation assessment scores in critically ill patients
J. Crit. Care 29(6) , 1132.e5-9, (2014) Purpose Patient-reported outcomes (PROs) are recommended as indicators of quality in the intensive care unit. We studied the correlation between PROs of sedation quality and a universal sedation assessment scale in critically ill patients. |
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The slow death of lethal injection.
BMJ 348 , g2670, (2014)
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The association between sedation practices and duration of mechanical ventilation in intensive care.
Anaesth. Intensive Care 41(3) , 311-5, (2013) Choice of sedation agent may influence duration of mechanical ventilation in the intensive care unit (ICU). We conducted a retrospective observational analysis of 2102 consecutive mechanically ventilated ICU patients over an eight-year period at a Melbourne m... |
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Propofol increases preload dependency in septic shock patients.
J. Surg. Res. 193(2) , 849-55, (2015) Predicting fluid responsiveness is crucial for fluid administration in septic shock patients. Midazolam and propofol decrease vascular tone and venous return, which may influence preload dependency. However, little is known about the effects of these two seda... |
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The combined effects of midazolam and propofol sedation on muscle power.
Anaesthesia 68(5) , 478-83, (2013) We performed a randomised, crossover study to investigate the effects of intravenous sedation on grip strength and bite force. Twenty male volunteers received a bolus intravenous injection of midazolam (0.02 mg.kg(-1)) together with a 30-min propofol infusion... |