Hydroxychloroquine sulfate
Hydroxychloroquine sulfate structure
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Common Name | Hydroxychloroquine sulfate | ||
|---|---|---|---|---|
| CAS Number | 747-36-4 | Molecular Weight | 433.950 | |
| Density | N/A | Boiling Point | 516.7ºC at 760 mmHg | |
| Molecular Formula | C18H28ClN3O5S | Melting Point | 240 °C | |
| MSDS | Chinese USA | Flash Point | 266.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery.
J. Interferon Cytokine Res. 35(3) , 143-56, (2015) Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DE... |
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A new trick for an ancient drug: quinine dissociates antiphospholipid immune complexes.
Lupus 24(1) , 32-41, (2014) Quinine, a quinoline derivative, is an ancient antipyretic drug with antimalarial properties that has been phased out by more effective synthetic candidates. In previous studies we discovered that hydroxychloroquine (HCQ), a synthetic antimalarial with struct... |
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Profound symptomatic hypogammaglobulinemia: a rare late complication after rituximab treatment for immune thrombocytopenia. Report of 3 cases and systematic review of the literature
Autoimmun. Rev. 13(10) , 1055-63, (2014) Introduction B-cell depletion with rituximab (RTX) is widely used to treat autoimmune diseases, especially as second-line therapy for immune thrombocytopenia (ITP). The incidence of RTX-induced hypogammaglobulinemia is unknown because of heterogeneous follow-... |
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The Rapalogue, CCI-779, improves salivary gland function following radiation.
PLoS ONE 9(12) , e113183, (2014) The standard of care for head and neck cancer typically includes surgical resection of the tumor followed by targeted head and neck radiation. However depending on tumor location and stage, some cases may not require surgical resection while others may be tre... |
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Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes.
Scand. J. Rheumatol. 44(1) , 74-9, (2015) Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme in the production of prostaglandin E2 (PGE2) and its expression is upregulated during inflammation. mPGES-1 is considered as a potential drug target for the treatment of arthritis to reduce ... |
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The influence of therapy on CD4+CD25(high)FOXP3+ regulatory T cells in systemic lupus erythematosus patients: a prospective study.
Scand. J. Rheumatol. 44(1) , 29-35, (2015) Regulatory T cells (Tregs) are inversely correlated to disease activity in systemic lupus erythematosus (SLE). However, little is known concerning the influence of immunosuppressive agents on Tregs, which was the objective of this study.Thirty-five patients w... |
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Hydroxychloroquine's Efficacy as an Antiplatelet Agent Study in Healthy Volunteers: A Proof of Concept Study.
J. Cardiovasc. Pharmacol. Ther. 20(2) , 174-80, (2015) With the inflammatory model of atherosclerosis taking center stage, anti-inflammatory drugs hold a promising place in the therapy of cardiovascular disease (CVD). Recent studies showed that hydroxychloroquine (HCQ) was protective against thrombovascular event... |
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Randomised comparison of initial triple DMARD therapy with methotrexate monotherapy in combination with low-dose glucocorticoid bridging therapy; 1-year data of the tREACH trial.
Ann. Rheum. Dis. 73(7) , 1331-9, (2014) To compare 1-year clinical efficacy of (1) initial triple disease-modifying antirheumatic drug therapy (iTDT) with initial methotrexate (MTX) monotherapy (iMM) and (2) different glucocorticoid (GC) bridging therapies: oral versus a single intramuscular inject... |
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Conventional triple therapy as good as etanercept for uncontrolled rheumatoid arthritis.
BMJ 346 , f3846, (2013)
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Surgical management of the juvenile idiopathic arthritis patient with multiple joint involvement.
Orthop. Clin. North Am. 45(4) , 435-42, (2014) Juvenile idiopathic arthritis (JIA) is recognized as a heterogenous group of disorders in which the common factor is persistent arthritis in at least 1 joint occurring before the age of 16 years. Although conservative management with nonsteroidal anti-inflamm... |