(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine
(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine structure
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Common Name | (1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine | ||
|---|---|---|---|---|
| CAS Number | 29841-69-8 | Molecular Weight | 212.290 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 353.9±37.0 °C at 760 mmHg | |
| Molecular Formula | C14H16N2 | Melting Point | 81-84ºC | |
| MSDS | Chinese USA | Flash Point | 199.9±26.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.
Arch. Biochem. Biophys. 564 , 244-53, (2014) The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through dire... |
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NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.
Bioorg. Med. Chem. 17 , 3456-62, (2009) We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)-enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine, flexible homeomorphs of the NMDA channel blocker MK-801. We also describe the synthesis of th... |
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Analysis of leucine enkephalin by high-performance liquid chromatography using enzymatic derivatization by tyrosinase and electrochemical or fluorescence detection.
J. Pharm. Biomed. Anal. 19(6) , 855-64, (1999) Two tyrosine specific, HPLC methods with either electrochemical (HPLC-ED) or fluorescence (HPLC-FL) detection are described for leucine-enkephalin (LE) in cerebrospinal fluid (CSF). Both approaches involve the hydroxylation of the Tyr1-moiety of LE by mushroo... |
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A new fluorogenic assay for tyrosine-containing peptides.
J. Pharm. Biomed. Anal. 9(7) , 557-63, (1991) A new tyrosine-specific LC assay with pre-column fluorogenic derivatization is described for Tyr-Gly as model peptide. o-Hydroxylation of the tyrosine residue with tyrosinase in the presence of ascorbic acid, followed by oxidation to the corresponding quinone... |
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Diphenylethanediamine (DPEDA) as chiral selector: VII. Efficient HPLC resolution of a series of underivatized diarylcarbinols on a chiral stationary phase based on C5-amide-bonded N-3,5-dinitrobenzyl-DPEDA.
Chirality 8(7) , 490-93, (1996) Fast and efficient baseline separation of asymmetrically substituted diarylmethanols and 1,1-diarylethanols was achieved on an endcapped, amide-linked N-3,5-dinitrobenzoylated, (R,R)-1,2-diphenyl-1,2-ethanediamine-derived chiral stationary phase (CSP). Optima... |
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Mukaiyama, T.
Aldrichimica Acta 29 , 59, (1996)
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Chenier, P.J. et al.
Tetrahedron Lett. 38 , 7341, (1997)
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