Levosimendan
Levosimendan structure
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Common Name | Levosimendan | ||
|---|---|---|---|---|
| CAS Number | 141505-33-1 | Molecular Weight | 280.285 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H12N6O | Melting Point | 216-219ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro.
Thromb. Haemost. 113(2) , 350-62, (2015) Levosimendan is a positive inotropic drug for the treatment of acute decompensated heart failure (HF). Clinical trials showed that levosimendan was particularly effective in HF due to myocardial infarction. Myocardial necrosis induces a strong inflammatory re... |
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Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.
Skelet. Muscle 5 , 12, (2015) Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the contractile strength of muscles of NM patients. Mutations in N... |
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A Bayesian network meta-analysis on the effect of inodilatory agents on mortality.
Br. J. Anaesth. 114 , 746-56, (2015) Inodilators are commonly used in critically ill patients, but their effect on survival has not been properly studied to date. The objective of this work was to conduct a network meta-analysis on the effects of inodilators on survival in adult cardiac surgery ... |
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Influence of levosimendan postconditioning on apoptosis of rat lung cells in a model of ischemia-reperfusion injury.
PLoS ONE 10(1) , e0114963, (2015) To ascertain if levosimendan postconditioning can alleviate lung ischemia-reperfusion injury (LIRI) in rats.One hundred rats were divided into five groups: Sham (sham), ischemia-reperfusion group (I/R group), ischemic postconditioning (IPO group), levosimenda... |
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The effects of levosimendan on brain metabolism during initial recovery from global transient ischaemia/hypoxia.
BMC Neurol. 12 , 81, (2012) Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved haemodynamic effect... |
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Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury.
BMC Neurol. 10 , 97, (2010) We investigated the neuroprotective properties of levosimendan, a novel inodilator, in an in vitro model of traumatic brain injury.Organotypic hippocampal brain slices from mouse pups were subjected to a focal mechanical trauma. Slices were treated after the ... |
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Effect of Levosimendan on Diastolic Function in Patients Undergoing Coronary Artery Bypass Grafting: A Comparative Study.
J. Cardiovasc. Pharmacol. 66 , 141-7, (2015) To compare the efficacy of levosimendan with nitroglycerin in patients with isolated diastolic dysfunction undergoing coronary artery bypass grafting.Thirty patients with isolated diastolic dysfunction undergoing on-pump coronary artery bypass grafting were r... |
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Single-centred experience with levosimendan in paediatric decompensated dilated cardiomyopathy.
Arch. Cardiovasc. Dis. 108 , 347-55, (2015) Children with dilated cardiomyopathy in advanced heart failure may spend a long time awaiting heart transplantation. Consequently, mechanical circulatory support is sometimes required as a bridge to transplantation. Levosimendan, a positive inotropic agent, h... |
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Effectiveness of prophylactic levosimendan in high-risk valve surgery patients.
Cardiovasc. J. S. Afr. 24 , 260-4, (2013) Levosimendan has anti-ischaemic effects, improves myocardial contractility and increases systemic, pulmonary and coronary vasodilatation. These properties suggest potential advantages in high-risk cardiac valve surgery patients where cardioprotection would be... |
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The effects of levosimendan and dobutamine in experimental bupivacaine-induced cardiotoxicity.
BMC. Anesthesiol. 13 , 28, (2013) Accidental intravenous exposure to bupivacaine is highly cardiotoxic and may lead to death. Positive inotropic agents are usually utilized in resuscitative efforts. We have compared the efficacy of levosimendan, a novel inotropic agent, with dobutamine and th... |