6-Hexanolactone

6-Hexanolactone Structure
6-Hexanolactone structure
Common Name 6-Hexanolactone
CAS Number 502-44-3 Molecular Weight 114.142
Density 1.0±0.1 g/cm3 Boiling Point 225.4±8.0 °C at 760 mmHg
Molecular Formula C6H10O2 Melting Point -1 °C
MSDS Chinese USA Flash Point 109.4±0.0 °C
Symbol GHS07
GHS07
Signal Word Warning

In vitro evaluation of effects of sustained anti-TNF release from MPEG-PCL-MPEG and PCL microspheres on human rheumatoid arthritis synoviocytes.

J. Biomater. Appl. 29(4) , 524-42, (2014)

Anti-tumor necrosis factor α (TNFα) drugs such as etanercept (ETN) have been mostly used in systemic treatment of rheumatoid arthritis. To eliminate the side effects in long-term treatments and to achieve a local sustained anti-inflammatory effect, a controll...

The imaging and the fractal metrology of chimeric liposomal Drug Delivery nano Systems: the role of macromolecular architecture of polymeric guest.

J. Liposome Res. 24(3) , 223-9, (2014)

The major advance of mixed liposomes (the so-called chimeric systems) is to control the size, structure, and morphology of these nanoassemblies, and therefore, system colloidal properties, with the aid of a large variety of parameters, such as chemical archit...

Polymeric nanoparticles-embedded organogel for roxithromycin delivery to hair follicles.

Eur. J. Pharm. Biopharm. 88(1) , 75-84, (2014)

Drug delivery into hair follicles with the use of nanoparticles (NPs) is gaining more importance as drug-loaded NPs may accumulate in hair follicle openings. The aim was to develop and evaluate a pluronic lecithin organogel (PLO) with roxithromycin (ROX)-load...

Influence of bone marrow-derived mesenchymal stem cells pre-implantation differentiation approach on periodontal regeneration in vivo.

J. Clin. Periodontol. 42 , 380-9, (2015)

The implantation of bone marrow-derived mesenchymal stem cells (MSCs) has previously been shown successful to achieve periodontal regeneration. However, the preferred pre-implantation differentiation strategy (e.g. maintenance of stemness, osteogenic or chond...

Poly (3-hydroxyalkanoates)-co-(6-hydroxyhexanoate) hydrogel promotes angiogenesis and collagen deposition during cutaneous wound healing in rats.

Biomed. Mater. 10 , 045001, (2015)

Wound management and healing in several physiological or pathological conditions, particularly when comorbidities are involved, usually proves to be difficult. This presents complications leading to socio-economic and public health burdens. The accelerative w...

Selenium-Substituted Hydroxyapatite/Biodegradable Polymer/Pamidronate Combined Scaffold for the Therapy of Bone Tumour.

Int. J. Mol. Sci. 16 , 22205-22, (2015)

The present study evaluated a new concept of combined scaffolds as a promising bone replacement material for patients with a bone tumour or bone metastasis. The scaffolds were composed of hydroxyapatite doped with selenium ions and a biodegradable polymer (li...

Polymeric micelles for pH-responsive delivery of cisplatin.

J. Drug Target. 22(7) , 629-37, (2014)

Methoxy poly(ethylene oxide)-block-poly-(α-carboxylate-ε-caprolactone) (PEO-b-PCCL) was used to develop pH-responsive polymeric micelles for the delivery of cisplatin (CDDP). Micelles were prepared through complexation of CDDP with the pendant carboxyl groups...

Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion.

Spine 40 , 613-21, (2015)

A rodent posterolateral spinal fusion model.This study evaluated a protamine-based polyelectrolyte complex (PEC) developed to use heparin in enhancing the biological activity of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) in spinal fusio...

Synthesis of binuclear phenoxyimino organoaluminum complexes and their use as the catalyst precursors for efficient ring-opening polymerisation of ε-caprolactone.

Dalton Trans. 42(34) , 12346-53, (2013)

A series of novel binuclear phenoxyimino organoaluminum complexes of the type [(RN=CH)C6H3OAlMe2]2 [R = C6H5 (2a), 2,6-(i)Pr2C6H3 (2b), 2,6-Ph2C6H3 (2c), adamantyl (2d), (t)Bu (2e)] have been prepared in high yields, and these complexes were identified by (1)...

Cryogel-PCL combination scaffolds for bone tissue repair.

J. Mater. Sci. Mater. Med. 26(3) , 123, (2015)

The present work describes the development and the evaluation of cryogel-poly-ε-caprolactone combinatory scaffolds for bone tissue engineering. Gelatin was selected as cell-interactive biopolymer to enable the adhesion and the proliferation of mouse calvaria ...