3-Isobutyl-1-methylxanthine
3-Isobutyl-1-methylxanthine structure
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Common Name | 3-Isobutyl-1-methylxanthine | ||
|---|---|---|---|---|
| CAS Number | 28822-58-4 | Molecular Weight | 222.244 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 445.6±37.0 °C at 760 mmHg | |
| Molecular Formula | C10H14N4O2 | Melting Point | 200-201 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 223.3±26.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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BBS4 directly affects proliferation and differentiation of adipocytes.
Cell. Mol. Life Sci. 71(17) , 3381-92, (2014) BBS4 is one of several proteins whose defects cause Bardet-Biedl syndrome (BBS), a multi-systemic disorder, manifesting with marked obesity. BBS4 polymorphisms have been associated with common non-syndromic morbid obesity. BBS4 obesity molecular mechanisms, a... |
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White-to-brown metabolic conversion of human adipocytes by JAK inhibition.
Nat. Cell Biol. 17(1) , 57-67, (2014) The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in wh... |
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Comparative in vitro study on magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived progenitor cells.
PLoS ONE 9(9) , e108055, (2014) Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplanted progenitor cells and develop successful cell therapies fo... |
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Autocrine/paracrine function of globular adiponectin: inhibition of lipid metabolism and inflammatory response in 3T3-L1 adipocytes.
J. Cell. Biochem. 116(5) , 754-66, (2015) Adiponectin is an adipose-derived hormone, with beneficial effects on insulin sensitivity and inflammation. The aim of this study was to clarify the autocrine/paracrine effects of globular adiponectin (gAd) administrated during differentiation on the function... |
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Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.
J. Biochem. Mol. Toxicol. 29(3) , 99-108, (2015) We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 13.2 μmol for 24 h and 89.4 ± 11.4 μmol in 48 h, whereas in ... |
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Effect of germinated brown rice extracts on pancreatic lipase, adipogenesis and lipolysis in 3T3-L1 adipocytes.
Lipids Health Dis. 13 , 169, (2014) This study investigated anti-obesity effects of seven different solvent (n-hexane, toluene, dicholoromethane, ethyl acetate, absolute methanol, 80% methanol and deionized water) extracts of germinated brown rice (GBR) on pancreatic lipase activity, adipogenes... |
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Mechanical stimulation of human tendon stem/progenitor cells results in upregulation of matrix proteins, integrins and MMPs, and activation of p38 and ERK1/2 kinases.
BMC Mol. Biol. 16 , 6, (2015) Tendons are dense connective tissues subjected periodically to mechanical stress upon which complex responsive mechanisms are activated. These mechanisms affect not only the development of these tissues but also their healing. Despite of the acknowledged impo... |
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ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes.
Biochem. Pharmacol. 90(4) , 406-13, (2014) Endothelin-1 (ET-1) induces lipolysis in adipocytes, where ET-1 chronic exposure results in insulin resistance (IR) through suppression of glucose transporter (GLUT)4 translocation to the plasma membrane and consequently glucose uptake. ARF6 small GTPase, whi... |
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Salacia reticulata has therapeutic effects on obesity.
J. Nat. Med. 68(4) , 668-76, (2014) Salacia reticulata Wight (S. reticulata) is a herbal medicine used for treatment of early diabetes in Ayurvedic medicine. In previous reports, the extract of S. reticulata showed preventive effects on obesity and various metabolic disorders and a suppressive ... |
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Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation.
Pigment Cell Melanoma Res. 27(6) , 1051-62, (2014) Mitochondrial dynamics control mitochondrial functions as well as their morphology. However, the role of mitochondrial dynamics in melanogenesis is largely unknown. Here, we show that mitochondrial dynamics regulate melanogenesis by modulating the ROS-ERK sig... |