Nimbolide
Nimbolide structure
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Common Name | Nimbolide | ||
|---|---|---|---|---|
| CAS Number | 25990-37-8 | Molecular Weight | 466.52 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 608.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H30O7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 321.9±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma.
Int. J. Mol. Sci. 16 , 23405-24, (2015) Osteosarcoma (OS) is a primary malignant tumor of bone and is most prevalent in children and adolescents. OS is frequently associated with pulmonary metastasis, which is the main cause of OS-related mortality. OS has a poor prognosis and is often unresponsive... |
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Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture.
Southeast Asian J. Trop. Med. Public Health 16(1) , 66-72, (1985) The terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit Plasmodium falciparum in culture with a moderate potency. The EC50 against the parasite line K1 from Thailand was approximately 2.0 microM (0.95 m... |
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Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells.
Tumour Biol. 36(10) , 7539-47, (2015) Nimbolide is a tetranortriterpenoid isolated from the leaves and flowers of Azadirachta indica which has been shown to exhibit anticancer, antioxidant, anti-inflammatory, and anti-invasive properties in a variety of cancer cells. However, the anti-tumor effec... |
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Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).
Phytother Res. 21(3) , 245-50, (2007) Nimbolide, a triterpenoid extracted from the flowers of the neem tree (Azadirachta indica), was found to have antiproliferative activity against some cancer cell lines. Treatment of cells with 0.5-5.0 microm concentrations of nimbolide resulted in moderate to... |