Zopiclone
Zopiclone structure
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Common Name | Zopiclone | ||
|---|---|---|---|---|
| CAS Number | 43200-80-2 | Molecular Weight | 388.808 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 580.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H17ClN6O3 | Melting Point | 1780C | |
| MSDS | Chinese USA | Flash Point | 305.0±30.1 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Sedative-hypnotics are widely abused by drivers apprehended for driving under the influence of drugs.
Ther. Drug Monit. 37 , 339-46, (2015) Sedative-hypnotics are commonly encountered in drivers apprehended for driving under the influence of drugs (DUID). Previous research has mainly concentrated on the residual effects of the drugs.In this study, the extent of sleep medication use and abuse amon... |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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The effect of excipients on the stability and phase transition rate of xylazine hydrochloride and zopiclone.
J. Pharm. Biomed. Anal. 107 , 168-74, (2015) The compatibility of thermodynamically unstable polymorph of two active pharmaceutical compounds (xylazine hydrochloride form X and zopiclone form C) with different excipients was investigated. The effects of the excipient and its amount in the sample on the ... |
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[Comparative evaluation of the hypnotic drugs under conditions of brain injury].
Eksp. Klin. Farmakol. 75(8) , 31-3, (2012) The effect of hypnotic drugs on the brain stability with respect to complete ischemia posttraumatic convulsive reactions and hypoxia has been studied in animals with model brain injury. It is established that zopiclone exhibits pronounced hypnotic effect duri... |
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Development and validation of a dynamic range-extended LC-MS/MS multi-analyte method for 11 different postmortem matrices for redistribution studies applying solvent calibration and additional (13)C isotope monitoring.
Anal. Bioanal. Chem 407 , 8681-712, (2015) Postmortem redistribution (PMR) is one of numerous problems in postmortem toxicology making correct interpretation of measured drug concentrations difficult or even impossible. Time-dependent PMR in peripheral blood and especially in tissue samples is still u... |
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Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
Cochrane Database Syst. Rev. 8 , CD009776, (2014) Shift work results in sleep-wake disturbances, which cause sleepiness during night shifts and reduce sleep length and quality in daytime sleep after the night shift. In its serious form it is also called shift work sleep disorder. Various pharmacological prod... |
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Simultaneous determination of zopiclone and its degradation product and main impurity (2-amino-5-chloropyridine) by micellar liquid chromatography with time-programmed fluorescence detection: preliminary investigation for biological monitoring.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 907 , 49-55, (2012) A simple and reliable HPLC method was developed and validated for the simultaneous determination of the hypnotic drug, zopiclone (ZPC) and its degradation product and main impurity, 2-amino-5-chloropyridine (ACP). The analyses were carried out on BDS Hypersil... |
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Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma.
J. Anal. Toxicol. 36(7) , 472-6, (2012) This paper reports an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method to quantitate 21 benzodiazepines, zolpidem and zopiclone in serum and plasma. After liquid-liquid extraction, an Acquity UPLC with a TQ Detector and BEH... |
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The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats.
Eur. Neuropsychopharmacol. 9 , 29, (1999) In order to investigate the relative efficacy and safety of zopiclone and zolpidem, we compared the effects of higher doses of zopiclone and zolpidem on the frequency of hippocampal theta activity and sleep structure with that of triazolam. Rats were divided ... |
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Muscle relaxants for pain management in rheumatoid arthritis.
Cochrane Database Syst. Rev. 1 , CD008922, (2012) Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such... |