AM1241
AM1241 structure
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Common Name | AM1241 | ||
|---|---|---|---|---|
| CAS Number | 444912-48-5 | Molecular Weight | 503.33 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 630.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H22IN3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 335.2±31.5 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain.
Pain 152 , 1976-87, (2011) Drug self-administration methods were used to test the hypothesis that rats would self-medicate with a cannabinoid CB(2) agonist to attenuate a neuropathic pain state. Self-medication of the CB(2) agonist (R,S)-AM1241, but not vehicle, attenuated mechanical h... |
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Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.
Proc. Natl. Acad. Sci. U. S. A. 100 , 10529-10533, (2003) We designed AM1241, a selective CB2 cannabinoid receptor agonist, and used it to test the hypothesis that CB2 receptor activation would reverse the sensory hypersensitivity observed in neuropathic pain states. AM1241 exhibits high affinity and selectivity for... |
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Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.
Br. J. Pharmacol. 162 , 428-40, (2011) Cannabinoid CB₂ receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB₂-mediated analgesic effects remain largely unknown. The present... |
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Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects.
Pharmacol. Biochem. Behav. 98 , 493-502, (2011) Cannabinoid CB(2) agonists produce antinociception without central nervous system (CNS) side-effects. This study was designed to characterize the pharmacological and antinociceptive profile of AM1710, a CB(2) agonist from the cannabilactone class of cannabino... |
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Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation.
AAPS J. 12 , 147-57, (2010) Cannabinoid CB(2) receptors represent a therapeutic target that circumvents unwanted central side effects (e.g., psychoactivity and/or addiction) associated with activation of CB(1) receptors. One of the primary investigative tools used to study functions of ... |
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Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Neuroscience 119 , 747-757, (2003) Activation of cannabinoid CB(2) receptors attenuates thermal nociception in untreated animals while failing to produce centrally mediated effects such as hypothermia and catalepsy [Pain 93 (2001) 239]. The present study was conducted to test the hypothesis th... |