Benazepril hydrochloride
Benazepril hydrochloride structure
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Common Name | Benazepril hydrochloride | ||
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| CAS Number | 86541-74-4 | Molecular Weight | 460.951 | |
| Density | N/A | Boiling Point | 691.2ºC at 760 mmHg | |
| Molecular Formula | C24H29ClN2O5 | Melting Point | 188-190°C | |
| MSDS | USA | Flash Point | 371.8ºC | |
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Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.
Drug Metab. Dispos. 42(9) , 1522-31, (2014) Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydr... |
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Trough:peak ratio of the blood pressure response to angiotensin converting enzyme inhibitors.
Med. Dosim. 12 , S91-S94, (1994) SHORT- VERSUS LONG-ACTING ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS: Although ACE inhibitors are widely used in the treatment of hypertension, there are few data on trough:peak ratios and the data are contradictory. Part of the explanation for this lies ... |
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Using ACE inhibitors appropriately.
Am. Fam. Physician 66 , 461-468, (2002) When first introduced in 1981, angiotensin-converting enzyme (ACE) inhibitors were indicated only for treatment of refractory hypertension. Since then, they have been shown to reduce morbidity or mortality in congestive heart failure, myocardial infarction, d... |
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Effects and clinical significance of pentoxifylline on the oxidative stress of rats with diabetic nephropathy.
J. Huazhong Univ. Sci. Technolog. Med. Sci. 35 , 356-61, (2015) Diabetic nephropathy (DN) is a common and serious clinical complication of diabetes and presently there are no effective ways to prevent its occurrence and progression. Recent studies show that pentoxifylline (PTX) can improve renal hemodynamics, reduce urina... |
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Liquid chromatography-tandem mass spectrometry method for determination of aliskiren in saliva and its application to a clinical trial with healthy volunteers.
J. Pharm. Biomed. Anal. 96 , 118-26, (2014) Although serum and plasma are the biological fluids of choice for pharmacokinetic determination of drugs in adults, it is desirable to elucidate noninvasive methods which can be used for investigations in vulnerable groups such as children. If the drug proper... |
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Simultaneous quantitative and qualitative analysis of aliskiren, enalapril and its active metabolite enalaprilat in undiluted human urine utilizing LC-ESI-MS/MS.
Biomed. Chromatogr. 28(12) , 1679-91, (2014) The benefit-risk ratio of combined blocking by the direct renin inhibitor aliskiren and an angiotensin-converting enzyme inhibitor (e.g. enalapril) on the renin-angiotensin-aldosterone system is discussed. No method was available for simultaneous determinatio... |
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The effects of antihypertensive agents on the survival rate of polycystic kidney disease in Han:SPRD rats.
Hypertens. Res. 25 , 939-943, (2002) Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder in humans. Hypertension is one of the major complications, and its control might affect the renal survival and disease mortality. Suitable antihypertensive agent... |