Daphnetin
Daphnetin structure
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Common Name | Daphnetin | ||
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| CAS Number | 486-35-1 | Molecular Weight | 178.14 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 430.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C9H6O4 | Melting Point | 265-268°C (dec.) | |
| MSDS | Chinese USA | Flash Point | 184.5±22.2 °C | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Thousands of chemical starting points for antimalarial lead identification.
Nature 465 , 305-10, (2010) Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with redu... |
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Expanding the ChemGPS chemical space with natural products.
J. Nat. Prod. 68 , 985-91, (2005) Recently various attempts have been made to increase the efficacy and precision of chemical libraries used in high-throughput screening (HTS) drug discovery approaches. One such approach is ChemGPS, which provides a defined chemical space for prescreening eva... |
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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proc. Natl. Acad. Sci. U. S. A. 104 , 20523-8, (2007) Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhibitors ha... |
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Medicinal chemistry as a conduit for the modulation of quorum sensing.
J. Med. Chem. 53 , 7467-89, (2010)
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Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.
Bioorg. Med. Chem. Lett. 18 , 1567-72, (2008) Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, ba... |
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In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis.
J. Pharm. Sci. 104 , 3557-64, (2015) The C-8 phenol group is essential to exert the bioactivities of daphnetin, but it is readily conjugated with glucuronic acid prior to excretion. In this study, daphnetin-7-methylether (7M-DNP) was used to investigate the effect of 7-methyl substitution on dap... |
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Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression
Environ. Toxicol. Pharmacol. 38(2) , 531-41, (2014) • This study demonstrates the hepatoprotective effect of umbelliferone and daphnetin. • Both coumarins ameliorate CCl4-induced oxidative stress and hepatotoxicity. • This effect is mediated via the nuclear translocation and accumulation of Nrf2. • Nrf2 up-reg... |
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Anti-inflammatory and protective properties of daphnetin in endotoxin-induced lung injury.
J. Agric. Food Chem. 62(51) , 12315-25, (2014) Uncontrolled inflammatory responses cause tissue injury and severe immunopathology. Pharmacological interference of intracellular pro-inflammatory signaling may confer a therapeutic benefit under these conditions. Daphnetin, a natural coumarin derivative, has... |