Daphnetin

Modify Date: 2024-01-02 16:27:10

Daphnetin structure	Common Name	Daphnetin
	CAS Number	486-35-1	Molecular Weight	178.14
	Density	1.6±0.1 g/cm3	Boiling Point	430.4±45.0 °C at 760 mmHg
	Molecular Formula	C₉H₆O₄	Melting Point	265-268°C (dec.)
	MSDS	Chinese USA	Flash Point	184.5±22.2 °C

Use of Daphnetin

Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively[1][2]. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has been clinically used in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties[3].

Name	7,8-dihydroxycoumarin
Synonym	More Synonyms

Description	Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively[1][2]. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has been clinically used in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties[3].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
Target	EGFR:7.67 μM (IC50) PKA:9.33 μM (IC50) PKC:25.01 μM (IC50)
References	[1]. Yang EB, et al. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem Biophys Res Commun. 1999 Jul 14;260(3):682-5. [2]. Lv H, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic Biol Med. 2017 May;106:38-52. [3]. Jiménez-Orozco FA, et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur J Pharmacol. 2011 Oct 1;668(1-2):35-41.

Density	1.6±0.1 g/cm3
Boiling Point	430.4±45.0 °C at 760 mmHg
Melting Point	265-268°C (dec.)
Molecular Formula	C₉H₆O₄
Molecular Weight	178.14
Flash Point	184.5±22.2 °C
Exact Mass	178.026611
PSA	70.67000
LogP	0.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.689

Daphnetin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6382600

CHEMICAL NAME :: Coumarin, 7,8-dihydroxy-

CAS REGISTRY NUMBER :: 486-35-1

BEILSTEIN REFERENCE NO. :: 0009372

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H6-O4

MOLECULAR WEIGHT :: 178.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 22,87,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 429 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 22,87,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 22,87,1987

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R25
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	GN6382600
HS Code	2942000000

Precursor 10
CAS#:617-48-1 (±)-Malic Acid CAS#:87-66-1 Pyrogallol CAS#:104819-86-5 7,8-dibenzyloxy... CAS#:471-25-0 Propiolic acidd
CAS#:2445-80-9 Daphnetin dimet... CAS#:19492-03-6 Daphnetin 7-met... CAS#:76474-93-6 7-methoxy-8-(3-... CAS#:108-24-7 Ethanoic anhydride
CAS#:110-16-7 Maleic acid CAS#:2067-86-9 7-Hydroxy-2-oxo...
DownStream 6
CAS#:19492-03-6 Daphnetin 7-met... CAS#:2445-80-9 Daphnetin dimet... CAS#:21784-71-4 2H-1-Benzopyran... CAS#:76474-93-6 7-methoxy-8-(3-...
CAS#:483-92-1 Luvangetin CAS#:485-90-5 Hydrangetin

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Daphnetin

7,8-Dihydroxychromen-2-one

7,8-Dihydroxycoumarin

7,8-dihydroxy-coumarin

2H-1-Benzopyran-2-one, 7,8-dihydroxy-

EINECS 207-632-8

7,8-Dihydroxy-2H-chromen-2-one

7,8-Dihydroxy-2H-1-benzopyran-2-one

MFCD00016977

TCMDC-125839

Shanghai Nianxing Industrial Co., Ltd
China
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China
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DC Chemicals Limited
China
Product Name: 7,8-Dihydroxycoumarin
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
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Daphnetin

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