4-Chlorophenylhydrazine hydrochloride
4-Chlorophenylhydrazine hydrochloride structure
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Common Name | 4-Chlorophenylhydrazine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1073-70-7 | Molecular Weight | 179.047 | |
| Density | 1.32g/cm3 | Boiling Point | 265.3ºC at 760mmHg | |
| Molecular Formula | C6H8Cl2N2 | Melting Point | 216 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 114.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Reaction of 3-acetonyl-5-cyano-1,2,4-thiadiazole with phenylhydrazine hydrochlorides: indolization and phenylpyrazolation.
Chem. Pharm. Bull. 48(1) , 160-2, (2000) Treatment of 3-acetonyl-5-cyano-1,2,4-thiadiazole (1) with 4-methyl or 4-methoxyphenylhydrazine hydrochloride provided 5-cyano-3-(2,5-dimethylindol-3-yl)-1,2,4-thiadiazole (2) or 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole (3) as the sole produ... |
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Reactions of prostaglandin H synthase with monosubstituted hydrazines and diazenes. Formation of iron(II)-diazene and iron(III)-sigma-alkyl or iron(III)-sigma-aryl complexes.
Eur. J. Biochem. 226(2) , 445-57, (1994) The reaction of p-chlorophenylhydrazine with prostaglandin H synthase (PGHS) Fe(III) under aerobic conditions leads to a partial destruction of the heme and to a new complex absorbing at 436 nm. This complex is also obtained by reaction of p-chlorophenyldiaze... |
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Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors.
Eur. J. Med. Chem. 45(4) , 1359-66, (2010) Biological screening of (hetero)aromatic compounds allowed the identification of some novel inhibitors of Abeta(1-40) aggregation, bearing indane and indole rings as common scaffolds. Molecular decoration of lead compounds led to inhibitors exhibiting a poten... |
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Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites.
Bioorg. Med. Chem. 14(11) , 3938-46, (2006) A series of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides bearing the halogens iodine and bromine were synthesised and their binding affinity for the peripheral benzodiazepine binding sites (PBBS) in rat kidney mitochondrial membranes was evaluated using [(3)H]... |