U-62066
U-62066 structure
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Common Name | U-62066 | ||
|---|---|---|---|---|
| CAS Number | 87151-85-7 | Molecular Weight | 425.39200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H30Cl2N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Early role of the κ opioid receptor in ethanol-induced reinforcement.
Physiol. Behav. 105(5) , 1231-41, (2012) Effects of early ethanol exposure on later ethanol intake emphasize the importance of understanding the neurobiology of ethanol-induced reinforcement early in life. Infant rats exhibit ethanol-induced appetitive conditioning and ethanol-induced locomotor acti... |
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Characterization of intraocular pressure responses of the Tibetan monkey (Macaca thibetana).
Mol. Vis. 17 , 1405-13, (2011) To characterize the effects of circadian rhythm, feeding time, age, general anesthesia, and ocular hypotensive compounds on intraocular pressure (IOP) of the Tibetan monkey (Macaca thibetana).Tibetan monkeys were trained for IOP measurement with the TonoVet® ... |
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Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors.
J. Pharmacol. Exp. Ther. 339 , 555-566, (2011) 2-Methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242) is a novel κ-opioid receptor (KOR) antagonist with high affinity for human (3 nM), rat (21 nM), and mouse (22 nM) KOR, a ∼ 20-fold reduced affinity for human μ-opioid r... |
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Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats
Pharmacol. Biochem. Behav. 94(2) , 244-9, (2009) Our previous work indicated that pretreatment with the selective kappa-opioid receptor (KOPr) agonist, U69593, attenuated the ability of priming injections of cocaine to reinstate extinguished cocaine-seeking behavior. The present study expanded these initial... |
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Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: differential effects across behavioral measures.
Pharmacol. Biochem. Behav. 77(1) , 49-57, (2004) It is well established that chronic exercise decreases sensitivity to mu opioid agonists; however, it is less clear what effects it has on kappa opioids. The purpose of the present study was to examine sensitivity to the effects of the selective, kappa opioid... |
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Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor.
Psychopharmacology 167(3) , 265-73, (2003) Cocaine and mu opioid agonists increase central dopamine concentrations and produce robust interactions at both neurochemical and behavioral levels. Although the interactions between cocaine and high-efficacy mu opioids have been well characterized, the inter... |
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Dissociation between sex differences in the immunological, behavioral, and physiological effects of kappa- and delta-opioids in Fischer rats.
Psychopharmacology 185(1) , 66-75, (2006) The sex of the individual can have a profound effect on sensitivity to the effects of opioids. Recently, our laboratory provided the first evidence that females may be more sensitive to the immune-altering effects of mu-opioids than males. However, it remains... |
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Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.
Am. J. Physiol. Heart Circ. Physiol. 294(1) , H205-12, (2008) Increased signaling by G(i)-coupled receptors has been implicated in dilated cardiomyopathy. To investigate the mechanisms, we used transgenic mice that develop dilated cardiomyopathy after conditional expression of a cardiac-targeted G(i)-coupled receptor (R... |
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Sex differences in (-)-pentazocine antinociception: comparison to morphine and spiradoline in four rat strains using a thermal nociceptive assay.
Behav. Pharmacol. 14(1) , 77-85, (2003) The present study examined the influence of sex on the antinociceptive effects of (-)-pentazocine, morphine and spiradoline in four rat strains, using a warm-water (50, 52 and 55 degrees C) tail-withdrawal procedure. In F344, Lewis, Sprague-Dawley (SD) and Wi... |
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Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.
Eur. J. Pharmacol. 557(1) , 32-6, (2007) Nociceptin/orphanin FQ (N/OFQ), a 17-amino-acid peptide, is an endogenous agonist whose receptor is similar in sequence to mu, delta and kappa opioid receptors. It has been reported that N/OFQ can block antinociceptive effects induced by opioid receptor agoni... |