Sildenafil
Sildenafil structure
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Common Name | Sildenafil | ||
|---|---|---|---|---|
| CAS Number | 139755-83-2 | Molecular Weight | 474.576 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 672.4ºC at 760 mmHg | |
| Molecular Formula | C22H30N6O4S | Melting Point | 187-189°C | |
| MSDS | N/A | Flash Point | 360.5ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.
Proc. Natl. Acad. Sci. U. S. A. 110(23) , 9451-6, (2013) Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by severe intestinal necrosis and for which breast milk represents the most effective protective strategy. Previous studies have revealed a critical role for the lipop... |
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Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatment.
J. Infect. Dis. 208(3) , 512-9, (2013) Shortening tuberculosis treatment could significantly improve patient adherence and decrease the development of drug resistance. Phosphodiesterase inhibitors (PDE-Is) have been shown to be beneficial in animal models of tuberculosis. We assessed the impact of... |
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Interventions to improve symptoms and quality of life of patients with fibrotic interstitial lung disease: a systematic review of the literature.
Thorax 68(9) , 867-79, (2013) Patients with fibrotic interstitial lung disease have symptom control and quality of life (QoL) needs. This review aims to evaluate the evidence for the use of interventions in improving dyspnoea, other symptoms and QoL.Eleven databases, relevant websites and... |
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Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators.
Am. J. Physiol. Lung Cell. Mol. Physiol. 306(2) , L207-15, (2014) Inhaled nitric oxide (NO) and other cGMP- or cAMP-dependent pulmonary vasodilators are often used in combination for the treatment of the persistent pulmonary hypertension of the newborn syndrome. There is in vitro evidence to indicate that NO downregulate th... |
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Right ventricular electrical remodeling and arrhythmogenic substrate in rat pulmonary hypertension.
Am. J. Respir. Cell. Mol. Biol. 49(3) , 426-36, (2013) Right ventricular (RV) dysfunction, caused by severe pulmonary hypertension (PH), is associated with high mortality because of RV failure. However, some patients can suffer from sudden cardiac death (SCD). We hypothesized that severe PH can cause RV arrhythmo... |
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Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study.
J. Basic Clin. Physiol. Pharmacol. 24(1) , 73-9, (2013) Altered regulation of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) is present in liver cirrhosis. Several experimental studies have shown that selective modulation of NO metabolism in the liver reduces intrahepatic resistance and portal pressure in c... |
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Novel microstructured sildenafil dosage forms as wound healing promoters.
Expert Opin. Drug Deliv. 11(10) , 1525-36, (2014) Study the possible benefit of combining biodegradable polymers with sildenafil citrate (SC) in wound healing.Biodegradable micronized powdered formulations of SC were prepared by spray drying using chitosan (P₁) or chitosan/gum Arabic (P₂). Powders were chara... |
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cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury.
J. Pharmacol. Exp. Ther. 347(3) , 626-34, (2013) Recent studies demonstrate that mitochondrial dysfunction is a mediator of acute kidney injury (AKI). Consequently, restoration of mitochondrial function after AKI may be key to the recovery of renal function. Mitochondrial function can be restored through th... |
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When to initiate intravenous therapy and/or refer.
Am. J. Cardiol. 111(8 Suppl) , 21C-4C, (2013) Intravenous (IV) prostacyclin (epoprostanol) and its analogs (iloprost and treprostinil) are effective in treating pulmonary artery hypertension (PAH). Although prostacyclins are available for inhaled and subcutaneous delivery, IV administration of prostacycl... |
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Serum homocysteine levels and sildenafil 50 mg response in young-adult male patients without vascular risk factors.
Indian J. Biochem. Biophys. 50(3) , 215-20, (2013) The aim of the present study was to investigate serum homocysteine levels in patients with erectile dysfunction and to evaluate the relationship between serum homocysteine levels and response to the standard 50 mg phosphodiesterase 5 inhibitor treatment. Twen... |