6-Methyluracil
6-Methyluracil structure
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Common Name | 6-Methyluracil | ||
|---|---|---|---|---|
| CAS Number | 626-48-2 | Molecular Weight | 126.113 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C5H6N2O2 | Melting Point | 318 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 208ºC | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial
Reprod. Toxicol. 28(4) , 503-10, (2009) The chick micromass culture system has advantages over the validated rat system – ready availability and non-culling of the donor parent – but needs to give comparable results. This study confirmed comparability and the ability to extend the system to cover c... |
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Arginine glutamate improves healing of radiation-induced skin ulcers in guinea pigs.
Int. J. Radiat. Biol. 89(12) , 1108-15, (2013) The increase in the incidence of the radiation-induced skin injury cases and the absence of standard treatments escalate the interest in finding new and effective drugs for these lesions. We studied the effect of a 40% solution of arginine glutamate on the he... |
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Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.
Bioorg. Med. Chem. Lett. 14(9) , 2269-74, (2004) The synthesis of a series of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils is discussed. SAR around N-1 of the uracil was explored, which led to the discovery that an electron-deficient 2,6-disubstituted benzyl group is required for ... |
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Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS).
Br. J. Pharmacol. 163(4) , 732-44, (2011) The rat respiratory muscle diaphragm has markedly lower sensitivity than the locomotor muscle extensor digitorum longus (EDL) to the new acetylcholinesterase (AChE) inhibitors, alkylammonium derivatives of 6-methyluracil (ADEMS). This study evaluated several ... |
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Tetrakis- and tris(1-Methyluracil) complexes of Pt(II): formation and properties of a carbon-bonded nucleobase species as well as of heternonuclear derivatives.
Inorg. Chem. 46(26) , 11356-65, (2007) The reaction of K2PtCl4 with an excess of 1-methyluracilate (1-MeU) in water at 60 degrees C leads to the formation of two major products, K2[Pt(1-MeU-N3)4].10H2O (1) and trans-K[Pt(1-MeU-N3)2(1-MeU-C5)(H2O)].3H2O (2). Addition of CuCl2 to an aqueous solution... |
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Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.
Bioorg. Med. Chem. Lett. 13(19) , 3317-22, (2003) A new class of small molecule GnRH antagonists, the 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils, was designed and a novel stereoselective synthesis for these compounds was developed. The stereochemical integrities of key intermediates (S)-6 ... |
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Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.
Bioorg. Med. Chem. Lett. 13(19) , 3311-5, (2003) The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed. Introduction of a small methyl substituent at the beta-position from N3 of the uracil improved the GnRH binding potency by 5- to 10-fold. The best compoun... |
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Synthesis of various 5-alkoxymethyluracil analogues and structure-cytotoxic activity relationship study.
Carbohydr. Res. 346(14) , 2136-44, (2011) A number of 5-alkoxymethyluracil analogues were synthesized to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their correspondin... |
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Pyrrolidino-DNA.
Nucleosides Nucleotides Nucleic Acids 22(5-8) , 1187-9, (2003) We synthesized pyrrolidino-C-nucleosides, incorporated them into oligodeoxynucleotides and investigated their pairing properties. The thermal duplex and triplex stabilities were measured. While triplex formation is destabilized in the case of pyrrolidino-pseu... |
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Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.
Chirality 17(9) , 559-64, (2005) 1-(2,6-Difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil (6), a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor, exists as a pair of atropisomers in solution, which was detected by ... |