Methanesulfonamide
Methanesulfonamide structure
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Common Name | Methanesulfonamide | ||
|---|---|---|---|---|
| CAS Number | 3144-09-0 | Molecular Weight | 95.12 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 208.2±23.0 °C at 760 mmHg | |
| Molecular Formula | CH5NO2S | Melting Point | 85-89 °C(lit.) | |
| MSDS | USA | Flash Point | 79.7±22.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner.
Arthritis. Res. Ther. 17 , 321, (2015) The endocannabinoid system modulates function of immune cells and mesenchymal cells such as fibroblasts, which contribute to cartilage destruction in rheumatoid arthritis (RA). The aim of the study was to determine the influence of N-acylethanolamines anandam... |
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Inhibition of cyclooxygenase-2 causes a decrease in coronary flow in diabetic mice. The possible role of PGE2 and dysfunctional vasodilation mediated by prostacyclin receptor.
J. Physiol. Biochem. 71 , 351-8, (2015) Several lines of evidence suggest that cyclooxygenase-2 (COX-2) activity can have a beneficial role in the maintenance of vascular tone of the blood vessels in diabetes. Specifically, the increased production of prostacyclin (PGI2) and prostaglandin E2 (PGE2)... |
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In vitro antitumor mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide.
Mol. Pharmacol. 87(1) , 18-30, (2015) ON01910.Na [sodium (E)-2-(2-methoxy-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)phenylamino)acetate; Rigosertib, Estybon], a styryl benzylsulfone, is a phase III stage anticancer agent. This non-ATP competitive kinase inhibitor has multitargeted activity, promo... |
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Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents.
Eur. J. Med. Chem. 49C , 397-405, (2012) A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. The synthesized compounds were also investigated for their gastric ulcerogenic p... |
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Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction.
Biochem. Pharmacol. 92(4) , 607-17, (2014) Growing evidence suggests that hepatic-insulin resistance is sufficient to promote progression to cardiovascular disease. We have shown previously that liver-specific protein-tyrosine-phosphatase 1B (PTP1B) deficiency improves hepatic-insulin sensitivity and ... |
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A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis.
J. Org. Chem. 72(21) , 8135-8, (2007) An efficient two-step strategy has been developed to access diversely functionalized benzylic sulfonamides. Execution of this strategy required the development of two reaction methods: the palladium-catalyzed cross-coupling of aryl halides with CH-acidic meth... |
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Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.
Bioorg. Med. Chem. Lett. 14(7) , 1683-8, (2004) The effect of methanesulfonamide (MeSO(2)NH) group on COX-2 inhibitory activity of 1,5-diarylpyrazole is described. While this group being at position-4 of the N(1)-phenyl ring was found to be ineffective, its installation at position-4 of the C-5 phenyl ring... |
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Metabolism of the prostaglandin fertility regulator sulprostone in monkeys.
Prostaglandins 24(3) , 341-50, (1982) The prostaglandin imide analog sulprostone (I) was labeled with tritium in the phenoxy ring to trace the fate of the prostanoic acid portion of the molecule and with carbon-14 in the methanesulfonimide moiety to trace the fate of that portion of the molecule.... |
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Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities.
Bioorg. Med. Chem. 17(16) , 6020-31, (2009) A novel series of indoline-based acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors with a methanesulfonamide group at the 5-position were synthesized and their lipophilicity and biological activities were evaluated. Hepatic ACAT inhibitory and anti-foam... |
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Development and validation of an LC-MS/MS method for determination of methanesulfonamide in human urine.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(22) , 2087-92, (2009) A sensitive and selective liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed and validated for the quantification of methanesulfonamide (MSA) in human urine. MSA is a potential in vivo metabolite of reparixin, a speci... |