Dimethylaminopropionitrile
Dimethylaminopropionitrile structure
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Common Name | Dimethylaminopropionitrile | ||
|---|---|---|---|---|
| CAS Number | 1738-25-6 | Molecular Weight | 98.14630 | |
| Density | 0.87 g/mL at 25 °C(lit.) | Boiling Point | 171 °C750 mm Hg(lit.) | |
| Molecular Formula | C5H10N2 | Melting Point | −43 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 145 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The urotoxic effects of N,N'-dimethylaminopropionitrile. 2. In vivo and in vitro metabolism.
Toxicol. Appl. Pharmacol. 110(1) , 61-9, (1991) The urotoxicity and metabolism of N,N'-dimethylaminopropionitrile (DMAPN) were investigated in male Sprague-Dawley rats. Animals treated with 525 mg DMAPN/kg or equimolar doses of commercially available potential DMAPN metabolites showed varying levels of uri... |
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Purification of RNA molecules by gel techniques.
Meth. Enzymol. 180 , 14-25, (1989)
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[Morbidity study of employees exposed to dimethylaminopropionitrile].
Zentralbl. Arbeitsmed. Arbeitsschutz. Prophyl. Ergonomie 32(5) , 181-4, (1982)
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Occupationally related neurologic abnormalities--Massachusetts.
MMWR Morb. Mortal. Wkly. Rep. 30(30) , 265-6, (1981)
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In vivo and in vitro release of cyanide from neurotoxic aminonitriles.
J. Toxicol. Environ. Health A 16(3-4) , 449-60, (1985) Cyanide release from neurotoxic aminonitriles was measured following in vitro incubation with both microsomes and liver slices. Investigation of cyanide released as urinary thiocyanate following ip aminonitrile administration to rats was also measured. The yi... |
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Role of monoamine oxidase in aminopropionitrile-induced neurotoxicity.
J. Toxicol. Environ. Health A 32(4) , 415-27, (1991) Oxidation of aminopropionitriles was measured in vitro with both rat liver mitochondria and bovine plasma monoamine oxidase (MAO). The nonneurotoxic aminonitrile beta-aminopropionitrile (BAPN) was oxidized at a significantly higher rate (p less than .05) than... |
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Studies on the mechanism of urotoxic effects of N,N'-dimethylaminopropionitrile in rats and mice. 1. Biochemical and morphologic characterization of the injury and its relationship to metabolism.
J. Toxicol. Environ. Health A 33(1) , 1-17, (1991) N,N'-Dimethylaminopropionitrile (DMAPN), a major component of the NIAX catalyst ESN, is known to cause urinary bladder dysfunction in exposed workers. In order to investigate the mechanism of DMAPN toxicity, we carried out time-course (0-72 h) and dose-respon... |
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Evaluation of the inhibition of glycolytic enzymes by the neurotoxicant dimethylaminopropionitrile.
J. Toxicol. Environ. Health A 16(3-4) , 469-79, (1985) The neurotoxic aminonitrile dimethylaminopropionitrile (DMAPN) inhibits the crystalline glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and fructose-6-phosphate kinase (phosphofructokinase, PFK). Preincubation of GAPDH with the aminonitril... |
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Unusual occupational toxins.
Occup. Med. 7(3) , 567-86, (1992) Occupational and environmental medicine affords encounters with many unusual toxins, ranging from exotic metals to rocket fuels. Twelve of the most unusual industrial toxins are reviewed here and their clinical manifestations and treatments explored: acetonit... |
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Acute urinary bladder toxicity of a polyurethane foam catalyst mixture: a possible new target organ for propionitrile derivative.
J. Environ. Pathol. Toxicol. 4(2-3) , 555-62, (1980) The toxicity of the mixture NIAX-ESN which contains 95% dimethylaminopropionitrile was evaluated in male rats. Large doses (2.0 ml/kg ip) rapidly produced CNS excitation followed by depression and death. The mixture (given orally as two doses of 0.31 or 0.62 ... |