Mefloquine hydrochloride
Mefloquine hydrochloride structure
|
Common Name | Mefloquine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 51773-92-3 | Molecular Weight | 378.312 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 415.7±40.0 °C at 760 mmHg | |
| Molecular Formula | C17H17ClF6N2O | Melting Point | 250-254ºC | |
| MSDS | Chinese USA | Flash Point | 205.2±27.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Preliminary investigation of the contribution of CYP2A6, CYP2B6, and UGT1A9 polymorphisms on artesunate-mefloquine treatment response in Burmese patients with Plasmodium falciparum malaria.
Am. J. Trop. Med. Hyg. 91(2) , 361-6, (2014) CYP2A6, CYP2B6, and UGT1A9 genetic polymorphisms and treatment response after a three-day course of artesunate-mefloquine was investigated in 71 Burmese patients with uncomplicated Plasmodium falciparum malaria. Results provide evidence for the possible link ... |
|
|
Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria.
Malaria Journal 14 , 130, (2015) Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria. In humans, CPS-CQ is strikingly more efficient than immunization with radiation attenuated sporozoit... |
|
|
Comparison between Flow Cytometry, Microscopy, and Lactate Dehydrogenase-Based Enzyme-Linked Immunosorbent Assay for Plasmodium falciparum Drug Susceptibility Testing under Field Conditions.
J. Clin. Microbiol. 53 , 3296-303, (2015) Flow cytometry is an objective method for conducting in vitro antimalarial sensitivity assays with increasing potential for application in field sites. We examined in vitro susceptibility to seven anti-malarial drugs for 40 fresh P. falciparum field isolates ... |
|
|
Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial.
Clin. Infect. Dis. 56(6) , e68-75, (2013) Urogenital schistosomiasis is a major public health problem in sub-Saharan Africa, and routine programs for screening and treatment of pregnant women are not established. Mefloquine-currently evaluated as a potential alternative to sulfadoxine-pyrimethamine a... |
|
|
Malaria.
Lancet 383(9918) , 723-35, (2014) Although global morbidity and mortality have decreased substantially, malaria, a parasite infection of red blood cells, still kills roughly 2000 people per day, most of whom are children in Africa. Two factors largely account for these decreases; increased de... |
|
|
Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation.
J. Biol. Chem. 288(38) , 27571-83, (2013) Changes in the regulation of connective tissue ATP-mediated mechano-transduction and remodeling may be an important link to the pathogenesis of chronic pain. It has been demonstrated that mast cell-derived histamine plays an important role in painful fibrotic... |
|
|
Inhibition of influenza virus replication by targeting broad host cell pathways.
PLoS ONE 9(10) , e110631, (2014) Antivirals that are currently used to treat influenza virus infections target components of the virus which can mutate rapidly. Consequently, there has been an increase in the number of resistant strains to one or many antivirals in recent years. Here we comp... |
|
|
Active sulforhodamine 101 uptake into hippocampal astrocytes.
PLoS ONE 7(11) , e49398, (2012) Sulforhodamine 101 (SR101) is widely used as a marker of astrocytes. In this study we investigated labeling of astrocytes by SR101 in acute slices from the ventrolateral medulla and the hippocampus of transgenic mice expressing EGFP under the control of the a... |
|
|
Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates.
Malaria Journal 13 , 228, (2014) Spreading resistance of Plasmodium falciparum to existing drugs calls for the search for novel anti-malarial drugs and combinations for the treatment of falciparum malaria.In vitro and ex vivo investigations were conducted with fresh P. falciparum field isola... |
|
|
Influence of mefloquine administration during early pregnancy on rat embryonic development.
Toxicol. Mech. Methods 25(2) , 105-12, (2015) Mefloquine (MQ) is a potent effective antimalarial drug against multiple drug-resistant Plasmodium falciparum. It has been proved that MQ can be given safely during the second and third trimesters. However, there is very limited information on the drug safety... |