N-Methylphenethylamine
N-Methylphenethylamine structure
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Common Name | N-Methylphenethylamine | ||
|---|---|---|---|---|
| CAS Number | 589-08-2 | Molecular Weight | 135.206 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 201.7±9.0 °C at 760 mmHg | |
| Molecular Formula | C9H13N | Melting Point | 0.93ºC | |
| MSDS | Chinese USA | Flash Point | 73.9±0.0 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Structure–activity correlations for β-phenethylamines at human trace amine receptor 1
Bioorg. Med. Chem. 16 , 7415-23, (2008) CoMFA 3D-QSAR studies on the potency of 68 β-phenethylamine analogs to activate hTAAR 1 (61% steric, 39% electrostatic) indicates that bulk both at nitrogen and 4-aryl leads to lower potency. |
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Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction-liquid chromatography-mass spectrometry with positive-ion electrospray ionization.
J. Chromatogr. A. 1232 , 19-26, (2012) The analysis of cellular metabolic processes is of fundamental biological interest. Cellular metabolites, such as the intermediates of the tricarboxylic acid (TCA) cycle, provide essential information about the metabolic state of the cell. Not only is the TCA... |
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A rapid, sensitive electron-capture gas chromatographic procedure for analysis of metabolites of N-methyl,N-propargylphenylethylamine, a potential neuroprotective agent.
J. Pharmacol. Toxicol. Methods 52(3) , 373-8, (2005) N-Methyl,N-propargyphenylethylamine (MPPE) is a novel analog of (-)-deprenyl, a drug prescribed for Parkinson's disease and shown to have neuroprotective and neurorescue properties in a wide variety of in vitro and in vivo models. MPPE is also neuroprotective... |
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Effects of alpha-carbon substituents on the N-demethylation of N-methyl-2-phenethylamines by rat liver microsomes.
Drug Metab. Dispos. 11(1) , 15-20, (1983) The effects of methyl, ethyl, isopropyl, isobutyl, and benzyl substituents at the alpha-carbon of N-methyl-2-phenethylamine on the kinetics of its N-demethylation in liver microsomes from both control and phenobarbital pretreated rats were studied. In control... |
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Self-administration of the endogenous trace amines beta-phenylethylamine, N-methyl phenylethylamine and phenylethanolamine in dogs.
J. Pharmacol. Exp. Ther. 222(1) , 52-60, (1982) beta-Phenylethylamine and phenylethanolamine are biogenic amines structurally related to amphetamine which are known to occur endogenously in trace amounts in mammalian brain. The purpose of the present experiments was to determine whether these endogenous bi... |
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Effects of phenolic monoamines on release of luteinizing hormone stimulated by gonadotropin-releasing hormone and on plasma adrenocorticotropic hormone, norepinephrine, and cortisol concentrations in wethers.
J. Anim. Sci. 72(2) , 464-9, (1994) Eighteen Suffolk and Suffolk x Hampshire wethers (56.3 +/- 1.3 kg) were used to determine the effects of naturally occurring amines, N-methyl-beta-phenethylamine (NMP) and tyramine (T), on plasma cortisol, norepinephrine (NE), ACTH, and GnRH-stimulated LH con... |
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Characterization of N-methylphenylethylamine and N-methylphenylethanolamine as substrates for type A and type B monoamine oxidase.
Biochem. Pharmacol. 29(19) , 2663-7, (1980)
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Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog.
J. Pharmacol. Exp. Ther. 223(1) , 190-6, (1982) Single i.v. doses of beta-phenylethylamine (PEA) and its N-methyl homolog (NMPEA) were administered to separate groups of five dogs. The dose- and time-related effects of these compounds were determined on pupil diameter, heart rate and body temperature. Bloo... |
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alpha-Benzyl-N-methylphenethylamine (BNMPA), an impurity of illicit methamphetamine synthesis: pharmacological evaluation and interaction with methamphetamine.
Drug Alcohol Depend. 39(2) , 83-9, (1995) Methamphetamine is a popular drug of abuse, readily synthesized in clandestine laboratories. Illicitly obtained methamphetamine is frequently impure, containing various purposefully added diluents and adulterants, as well as impurities of manufacture and orig... |
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Follicular dynamics, embryo production, and hormonal responses in Brahman heifers following sympathetic stimulation.
J. Anim. Sci. 72(11) , 2948-54, (1994) The purpose of this experiment was to characterize adrenal and ovarian responses to N-methyl-beta-phenethylamine (NMP) or ACTH. Thirty-three heifers with functional midcycle corpora lutea were placed on a 4-d superovulation regimen. They were injected twice d... |