4-Bromo-antibiotic
4-Bromo-antibiotic structure
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Common Name | 4-Bromo-antibiotic | ||
|---|---|---|---|---|
| CAS Number | 76455-48-6 | Molecular Weight | 602.51700 | |
| Density | 1.43g/cm3 | Boiling Point | 735.4ºC at 760 mmHg | |
| Molecular Formula | C29H36BrN3O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 398.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Mast cell histamine-induced calcium transients in cultured human peritoneal mesothelial cells.
Perit. Dial. Int. 18(6) , 626-36, (1998) Peritoneal inflammation results from a complex interplay of events initiated by macrophage activity in response to infection, with the stimulation of mesothelial cell cytokine release amplifying the recruitment of blood-borne defense cells to the site of inju... |
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Activity-dependent development of calcium regulation in growing motor axons.
J. Neurosci. 18(13) , 4966-72, (1998) In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2+ ionophore application, normally active tonic motor axons ... |
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Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.
J. Biol. Chem. 284(29) , 19744-53, (2009) The Na/H exchanger 3 (NHE3) and the Cl/HCO(3) exchanger down-regulated in adenoma (DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca(2+)(i) inhibits NHE3 through mechanisms involving the PDZ domain proteins NHE3 kinase A regulato... |
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Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by atrial natriuretic peptide.
Immunol. Cell Biol. 79(1) , 11-7, (2001) Atrial natriuretic peptide (ANP) attenuates LPS-induced inducible nitric oxide synthase (iNOS) expression in murine macrophages by destabilizing iNOS mRNA. Because elevated intracellular free Ca2+ levels [Ca2+]i reduce iNOS mRNA stability, the aim of the pres... |
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Inverse regulation of the cytosolic Ca²⁺ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axis.
PLoS ONE 7(9) , e44837, (2012) Skeletal muscles show a high plasticity to cope with various physiological demands. Different muscle types can be distinguished by the force, endurance, contraction/relaxation kinetics (fast-twitch vs. slow-twitch muscles), oxidative/glycolytic capacity, and ... |
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ATP2C1 is specifically localized in the basal layer of normal epidermis and its depletion triggers keratinocyte differentiation.
J. Dermatol. Sci. 43(1) , 21-33, (2006) ATP2C1 is a calcium/manganese-ATPase localized in the Golgi apparatus and known as responsible gene for Hailey-Hailey disease. But its localization and roles in the epidermis are not fully elucidated.To explore the localization and biological role of ATP2C1 i... |
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Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells.
Cell Calcium 33(2) , 101-12, (2003) We have used fluorescence digital imaging techniques to explore the actions of two groups of Ca(2+) ionophores: (i). ferutinin, an electrogenic naturally occurring ionophore, and (ii). the neutral ionophores 4-BrA23187 and ionomycin, on cytosolic [Ca(2+)] ([C... |
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Monitoring neuronal calcium signalling using a new method for ratiometric confocal calcium imaging.
Cell Calcium 34(3) , 295-303, (2003) Ca2+ signalling influences many processes in the adult and developing nervous system like exocytosis, synaptic plasticity, and growth cone motility. Optical techniques in combination with fluorescent Ca2+ indicators are the most frequently used methods to mea... |
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Myopathy in broiler chickens: a role for Ca(2+)-activated phospholipase A2?
Poult. Sci. 82(8) , 1307-12, (2003) The role of Ca(2+)-dependent phospholipase A2 (PLA2) in the mechanism of skeletal muscle damage in broiler chickens was examined in vitro using a novel, synthetic, PLA2-specific inhibitor Ro31-499/001 (Ro31). Muscle damage was assessed by measurement of creat... |
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Effects of bicarbonate buffered dialysate on human peritoneal mesothelial cell intracellular calcium homeostasis.
Nephrology (Carlton.) 8(3) , 150-5, (2003) This study compares the biocompatibility of two bicarbonate-based peritoneal dialysis (PD) solutions using the measurement of intracellular free calcium (Ca(i)2+)) as a sensitive parameter of cell function in human peritoneal mesothelial cells (hPMC). Fura-2-... |