3-Methoxy-5-(trifluoromethyl)aniline
3-Methoxy-5-(trifluoromethyl)aniline structure
|
Common Name | 3-Methoxy-5-(trifluoromethyl)aniline | ||
|---|---|---|---|---|
| CAS Number | 349-55-3 | Molecular Weight | 191.150 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 242.0±40.0 °C at 760 mmHg | |
| Molecular Formula | C8H8F3NO | Melting Point | 50-52 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 100.2±27.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Bioorg. Med. Chem. Lett. 18(23) , 6231-5, (2008) A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and potent inhibition in mast cell degranulation assays. |
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