bruneomycin
bruneomycin structure
|
Common Name | bruneomycin | ||
|---|---|---|---|---|
| CAS Number | 3930-19-6 | Molecular Weight | 506.46400 | |
| Density | 1.54g/cm3 | Boiling Point | 719ºC at 760mmHg | |
| Molecular Formula | C25H22N4O8 | Melting Point | 301-303℃ | |
| MSDS | Chinese USA | Flash Point | 388.7ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
|
|
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors
Bioorg. Med. Chem. Lett. 19 , 6793-6, (2009) The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have bee... |
|
|
High-content single-cell drug screening with phosphospecific flow cytometry.
Nat. Chem. Biol. 4 , 132-42, (2008) Drug screening is often limited to cell-free assays involving purified enzymes, but it is arguably best applied against systems that represent disease states or complex physiological cellular networks. Here, we describe a high-content, cell-based drug discove... |
|
|
Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.
Bioorg. Med. Chem. Lett. 19 , 418-23, (2009) The essential enzyme thymidylate synthase-dihydrofolate reductase (TS-DHFR) is a validated drug target for many pathogens, but has been elusive in Cryptosporidium hominis, as active site inhibitors of the enzymes from related parasitic protozoa show decreased... |
|
|
Borrelia burgdorferi, a pathogen that lacks iron, encodes manganese-dependent superoxide dismutase essential for resistance to streptonigrin.
J. Biol. Chem. 287(23) , 19284-93, (2012) Borrelia burgdorferi, the causative agent of Lyme disease, exists in nature through a complex life cycle involving ticks of the Ixodes genus and mammalian hosts. During its life cycle, B. burgdorferi experiences fluctuations in oxygen tension and may encounte... |
|
|
Erwinia chrysanthemi iron metabolism: the unexpected implication of the inner membrane platform within the type II secretion system.
J. Bacteriol. 191(3) , 795-804, (2009) The type II secretion (T2S) system is an essential device for Erwinia chrysanthemi virulence. Previously, we reported the key role of the OutF protein in forming, along with OutELM, an inner membrane platform in the Out T2S system. Here, we report that OutF c... |
|
|
Iron transport in Francisella in the absence of a recognizable TonB protein still requires energy generated by the proton motive force.
Biometals 22(2) , 337-44, (2009) The mechanism of iron transport in Francisella is still a puzzle since none of the sequenced Francisella strains appears to encode a TonB protein, the energy transducer of the proton motive force necessary to act on the bacterial outer membrane siderophore re... |
|
|
Analysis of spontaneous and streptonigrin-induced sister chromatid exchanges in peripheral lymphocytes of aircrew members of international flights.
J. Environ. Pathol. Toxicol. Oncol. 27(4) , 277-85, (2008) In this work, we extend our previous studies concerning mutagen sensitivity in flight personnel from commercial airlines by analyzing the frequency of spontaneous and streptonigrin (SN)-induced sister chromatid exchanges (SCEs) in peripheral blood lymphocytes... |
|
|
[Effects of endovascular therapy for renal artery stenosis on blood pressure and renal function: retrospective analysis of an unselected patient collective from 1994 to 2007].
Urologe. A 51(11) , 1562-71, (2012) A retrospective analysis of the long-term success rates of endoluminal therapy of renal artery stenosis in a university hospital was carried out.Preinterventional and postinterventional data contained in the clinical records of all 104 patients who underwent ... |
|
|
A novel streptococcal integrative conjugative element involved in iron acquisition.
Mol. Microbiol. 70(5) , 1274-92, (2008) In this study, we determined the function of a novel non-ribosomal peptide synthetase (NRPS) system carried by a streptococcal integrative conjugative element (ICE), ICESe2. The NRPS shares similarity with the yersiniabactin system found in the high-pathogeni... |