1400W dihydrochloride
1400W dihydrochloride structure
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Common Name | 1400W dihydrochloride | ||
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| CAS Number | 214358-33-5 | Molecular Weight | 250.168 | |
| Density | N/A | Boiling Point | 329ºC at 760 mmHg | |
| Molecular Formula | C10H17Cl2N3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 152.7ºC | |
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NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
Am. J. Physiol. Renal Physiol. 308(3) , F244-51, (2015) With an increase in urine flow there is a significant increase in shear stress against the renal epithelium including the inner medullary collecting duct, resulting in an increase in nitric oxide (NO) production. The mechanisms of the shear stress-mediated in... |
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Gardenamide A Protects RGC-5 Cells from H₂O₂-Induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway.
Int. J. Mol. Sci. 16 , 22350-67, (2015) Gardenamide A (GA) protects the rat retinal ganglion (RGC-5) cells against cell apoptosis induced by H₂O₂. The protective effect of GA was completely abrogated by the specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002, and the specific protein kinas... |
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Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.
Cancer Res. 57 , 3300, (1997) We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is e... |
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1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo.
J. Biol. Chem. 272 , 4959, (1997) N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constan... |