20-HETE
20-HETE structure
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Common Name | 20-HETE | ||
|---|---|---|---|---|
| CAS Number | 79551-86-3 | Molecular Weight | 320.47 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 482.0±33.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 259.4±21.9 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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HMDB: a knowledgebase for the human metabolome.
Nucleic Acids Res. 37(Database issue) , D603-10, (2009) The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Si... |
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite ref... |
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
J. Cereb. Blood Flow Metab. 34(12) , 1887-97, (2014) Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the importance of the age-related decline in circulating insulin-... |
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Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE.
Prostaglandins Other Lipid Mediat. 116-117 , 88-98, (2015) Clinical studies suggest cardiovascular and renal benefits of ingesting small amounts of ethanol. Effects of ethanol, role of alcohol dehydrogenase (ADH) or of 20-hydroxyeicosatetraenoic acid (20-HETE) in podocytes of the glomerular filtration barrier have no... |
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UHPLC-MS/MS analysis of arachidonic acid and 10 of its major cytochrome P450 metabolites as free acids in rat livers: effects of hepatic ischemia.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 964 , 153-63, (2014) The cytochrome P450 metabolites of arachidonic acid (AA) are mostly present in tissues, such as the liver, as bound to phospholipids, with only a small fraction available as free acids. The purpose of this study was to develop and validate a UHPLC-MS/MS metho... |
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20-Hydroxyeicosatetraenoic Acid Is a Key Mediator of Angiotensin II-induced Apoptosis in Cardiac Myocytes.
J. Cardiovasc. Pharmacol. 66 , 86-95, (2015) Cardiomyocyte apoptosis is involved in a variety of cardiac stresses, including ischemia-reperfusion injury, heart failure, and cardiomyopathy. Both Angiotensin II (Ang II) and 20-hydroxyeicosatetraenoic acid (20-HETE) induce apoptosis in cardiomyocytes. Here... |
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Lipidomics reveals a remarkable diversity of lipids in human plasma.
J. Lipid Res. 51(11) , 3299-305, (2010) The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians r... |
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Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients.
Hypertens. Res. 31(4) , 623-32, (2008) Abnormal fatty acid metabolism may play an important role in the pathogenesis of essential hypertension (EH). We compared fasting serum free fatty acid (FFA) composition between EH patients and nonhypertensive (NH) subjects, and examined the relationships bet... |
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Analysis of biogenic amines in plasma of hypertensive patients and a control group.
Neurochem. Res. 18(11) , 1179-82, (1993) Procedures were developed for the determination of 17 circulating amines using gas chromatography-negative ion chemical ionisation mass spectrometry. The amines were quantified against their appropriate deuterated isotopomers. The mean concentrations and rang... |
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Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study.
Am. J. Hypertens. 16(7) , 522-30, (2003) The major aldosterone metabolite 3 alpha,5 beta tetrahydroaldosterone reflects up to 45% of the aldosterone secretion. Its 24-h urinary excretion is likely to provide an accurate index of the daily aldosterone production and to be an indicator for primary ald... |