Ethacrynic acid
Ethacrynic acid structure
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Common Name | Ethacrynic acid | ||
|---|---|---|---|---|
| CAS Number | 58-54-8 | Molecular Weight | 303.13800 | |
| Density | 1.35g/cm3 | Boiling Point | 480ºC at 760mmHg | |
| Molecular Formula | C13H12Cl2O4 | Melting Point | 125 °C | |
| MSDS | Chinese USA | Flash Point | 244.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
Mol. Cell Biochem. 393(1-2) , 209-22, (2014) Cytochrome P4502E1 (CYP2E1), glutathione-S-transferase A4-4 (GSTA4-4), and inducible nitric oxide synthase (iNOS) are implicated in maneb- and paraquat-induced toxicity leading to various pathological conditions. The study aimed to investigate the role of CYP... |
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Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.
Biochim. Biophys. Acta 1840(9) , 2851-61, (2014) Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis was identified as a new member of the recently discovered Din... |
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Differential involvement of glutathione S-transferase mu 1 and multidrug resistance protein 1 in melanoma acquired resistance to vinca alkaloids.
Fundam. Clin. Pharmacol. 29(1) , 62-71, (2015) On account of its extreme intrinsic resistance to apoptosis and of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) is still a therapeutic challenge. We previously showed that glutathione S-transferase mu ... |
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Development of enhanced capacity affinity microcolumns by using a hybrid of protein cross-linking/modification and immobilization.
J. Chromatogr. A. 1400 , 82-90, (2015) A hybrid method was examined for increasing the binding capacity and activity of protein-based affinity columns by using a combination of protein cross-linking/modification and covalent immobilization. Various applications of this approach in the study of dru... |
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15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.
Chem. Biol. Interact. 234 , 144-53, (2015) Bioactive lipids govern cellular homeostasis and pathogenic inflammatory processes. Current dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by 15-hydroxyprostaglandin dehydrogenase (15PGDH). In contrast, the present res... |
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Some insights on the description of gradient elution in reversed-phase liquid chromatography.
J. Sep. Sci. 37(17) , 2269-77, (2014) The so-called "fundamental equation for gradient elution" has been used for modeling the retention in gradient elution. In this approach, the instantaneous retention factor (k) is expressed as a function of the change in the modifier content (φ(ts )), ts bein... |
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Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab. Dispos. 43 , 851-63, (2015) Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to ... |
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Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions.
Anal. Chim. Acta 853 , 637-46, (2014) The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic doping agents was analyzed, in both ESI+ and ESI- modes. Th... |
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Target Fishing by Cross-Docking to Explain Polypharmacological Effects.
ChemMedChem 10 , 1209-17, (2015) Drugs may have polypharmacological phenomena, that is, in addition to the desired target, they may also bind to many undesired or unknown physiological targets. As a result, they often exert side effects. In some cases, off-target interactions may lead to dru... |
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ID helix-loop-helix proteins as determinants of cell survival in B-cell chronic lymphocytic leukemia cells in vitro.
Mol. Cancer 14 , 30, (2015) Members of the inhibitor of DNA-binding (ID) family of helix-loop-helix proteins have been causally implicated in the pathogenesis of several types of B-cell lineage malignancy, either on the basis of mutation or by altered expression. B-cell chronic lymphocy... |