2-Bromo-3-nitrobenzoic acid

2-Bromo-3-nitrobenzoic acid Structure
2-Bromo-3-nitrobenzoic acid structure
Common Name 2-Bromo-3-nitrobenzoic acid
CAS Number 573-54-6 Molecular Weight 246.02
Density 1.9±0.1 g/cm3 Boiling Point 337.7±32.0 °C at 760 mmHg
Molecular Formula C7H4BrNO4 Melting Point 184-186 °C(lit.)
MSDS Chinese USA Flash Point 158.1±25.1 °C
Symbol GHS07
GHS07
Signal Word Warning

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

Bioorg. Med. Chem. 21(17) , 5218-27, (2013)

Poly(ADP-ribose)polymerase-1 (PARP-1) is an important target for drug design for several therapeutic applications. 5-Aminoisoquinolin-1-one (5-AIQ) is a highly water-soluble lead compound; synthetic routes to 3-substituted analogues were explored. Tandem Hurt...

Preparation and NMR analysis of 2, 6-heterodifunctional halobenzenes as precursors for substituted biphenyls Sienkowska M, et al.

Tetrahedron 56(2) , 165-73, (2000)