Genistein
Genistein structure
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Common Name | Genistein | ||
|---|---|---|---|---|
| CAS Number | 446-72-0 | Molecular Weight | 270.237 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 555.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O5 | Melting Point | 297-298 °C | |
| MSDS | Chinese USA | Flash Point | 217.1±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
Nat. Commun. 6 , 6240, (2015) Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein f... |
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A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.
Toxicol. Appl. Pharmacol. 283(3) , 187-97, (2015) Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against ... |
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Direct cellular delivery of human proteasomes to delay tau aggregation.
Nat. Commun. 5 , 5633, (2014) The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevation of proteasomal activity is tolerable to cells and may be... |
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Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro.
Climacteric 17(6) , 682-91, (2014) To explore the effect and pathway of phytoestrogens in vitro on the growth of both normal and malignant breast cells.Normal breast MCF-10A cells and breast cancer MCF-7 cells were incubated with 10 (-10)-10(-4) mol/l genistein, resveratrol, and quercetin (pl... |
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Comparing morphological, chemical and anti-diabetic characteristics of Puerariae Lobatae Radix and Puerariae Thomsonii Radix.
J. Ethnopharmacol. 164 , 53-63, (2015) Puerariae Lobatae Radix (PLR) and Puerariae Thomsonii Radix (PTR) are traditional Chinese medicines used for the treatment of diabetes and cardiovascular diseases. These two herbs are used interchangeably in clinical practice, even though they possess signifi... |
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A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.
Fitoterapia 98 , 11-21, (2014) The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAC... |
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TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer.
Int. J. Mol. Sci. 16 , 10411-25, (2015) The Wnt/β-catenin pathway plays an essential role in the tumorigenesis of colorectal cancer. T-cell factor-4 (TCF4) is a member of the TCF/LEF (lymphoid enhancer factor) family of transcription factors, and dysregulation of β-catenin is decisive for the initi... |
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A novel UHPLC method for the rapid and simultaneous determination of daidzein, genistein and equol in human urine.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1005 , 1-8, (2015) This work reports on a novel method involving reverse-phased ultra-high performance liquid chromatography (UHPLC) plus a spectrophotometric photodiode array/fluorescence (FLR) detection system for determining the concentration of equol and major soy isoflavon... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.
J. Chromatogr. A. 1396 , 62-71, (2015) Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chromatography. The obtained columns of tricationic ionic liqu... |