normeperidine
normeperidine structure
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Common Name | normeperidine | ||
|---|---|---|---|---|
| CAS Number | 77-17-8 | Molecular Weight | 233.30600 | |
| Density | 1.064 g/cm3 | Boiling Point | 333.5ºC at 760 mmHg | |
| Molecular Formula | C14H19NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 11 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Use of meperidine in patient-controlled analgesia and the development of a normeperidine toxic reaction.
Arch. Surg. 137(1) , 84-8, (2002) Intravenous patient-controlled analgesia (IV PCA) meperidine hydrochloride can be used with a reasonable margin of safety.A retrospective review was performed of 355 medical records of patients receiving IV PCA meperidine treatment. Four groups of patients we... |
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Urinary excretion of meperidine and normeperidine in man upon acute and chronic exposure to high altitude.
Methods Find. Exp. Clin. Pharmacol. 18(1) , 49-53, (1996) The urinary excretion of unchanged meperidine (M) varies with change of pH and metabolism. Since exposure of man to high altitude (H) may cause significant physiologic changes, we investigated its effects on the urinary excretion of M. The study was carried o... |
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Meperidine in patient-controlled analgesia: a near-fatal mishap.
Anesth. Analg. 76(3) , 655-7, (1993)
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Meperidine-induced generalized seizures with normal renal function.
South. Med. J. 90(5) , 556-8, (1997) Meperidine is a widely prescribed opioid analgesic used in a variety of clinical situations. The parent compound has central nervous system depressant effects. However, the sole active metabolite, normeperidine, is a central nervous system excitatory agent an... |
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The effect of ritonavir on the pharmacokinetics of meperidine and normeperidine.
Pharmacotherapy 20(5) , 549-53, (2000) To determine the effects of ritonavir on the pharmacokinetics of meperidine and normeperidine.Open-label, crossover, pharmacokinetic study.United States government research hospital.Eight healthy volunteers who tested negative for the human immunodeficiency v... |
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Behavioural effects of norpethidine, a metabolite of pethidine, in rats.
Toxicology 95(1-3) , 37-44, (1995) This study investigated behavioural effects of the toxic pethidine metabolite, norpethidine, in rats and its interactions with reserpine, apomorphine and physostigmine. Following intraperitoneal administration, brain concentrations of norpethidine reached a p... |
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Successful treatment of normeperidine neurotoxicity by hemodialysis.
Am. J. Kidney Dis. 35(1) , 146-9, (2000) Normeperidine, a major metabolite of meperidine, is half as potent as meperidine as an analgesic but two to three times more potent as a convulsant. Renal failure significantly increases the plasma half-life of normeperidine. The intensity of the central nerv... |
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Pethidinic acid: corroboration of a doctor's denial of pethidine re-use.
J. Anal. Toxicol. 37(3) , 179-81, (2013) Pethidine (meperidine), a synthetic opiate, formally used as an analgesic in surgery and obstetrics, has been an abused drug of choice for some doctors. A case is presented in which a doctor, who previously admitted to using pethidine, was suspected of re-usi... |
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Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
Bioorg. Med. Chem. 18 , 8356-64, (2010) A series of benzyl esters of meperidine and normeperidine were synthesized and evaluated for binding affinity at serotonin, dopamine and norepinephrine transporters. The 4-methoxybenzyl ester 8b and 4-nitrobenzyl ester 8c in the meperidine series and 4-methox... |
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Norpethidine accumulation and generalized seizure during pethidine patient-controlled analgesia.
Anaesth. Intensive Care 27(3) , 289-91, (1999) A 35-year-old, 47 kg female presented for elective laparatomy, adhesiolysis and ileostomy formation. Pre-existing neurological problems precluded placement of an epidural and IV PCA was used for postoperative analgesia. A patient request for pethidine was all... |