Nicergoline
Nicergoline structure
|
Common Name | Nicergoline | ||
|---|---|---|---|---|
| CAS Number | 27848-84-6 | Molecular Weight | 484.385 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 594.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H26BrN3O3 | Melting Point | 136-138° | |
| MSDS | Chinese USA | Flash Point | 313.3±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Structural alteration of cell surface heparan sulfate through the stimulation of the signaling pathway for heparan sulfate 6-O-sulfotransferase-1 in mouse fibroblast cells.
Biosci. Biotechnol. Biochem. 78(5) , 770-9, (2014) Heparan sulfate (HS) is a randomly sulfated polysaccharide that is present on the cell surface and in the extracellular matrix. The sulfated structures of HS were synthesized by multiple HS sulfotransferases, thereby regulating various activities such as grow... |
|
|
[Nicergoline, ibudilast, ifenprodil tartrate].
Nihon Rinsho. 64 Suppl 7 , 602-5, (2006)
|
|
|
Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes.
Brain Res. 1066(1-2) , 78-85, (2005) We examined the neuroprotective role of nicergoline in neuron-microglia or neuron-astrocytes co-cultures. Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture with activated microglia or astrocytes stimul... |
|
|
Smart stability-indicating spectrophotometric methods for determination of binary mixtures without prior separation.
J. AOAC Int. 91(2) , 299-310, (2008) Ratio subtraction and isosbestic point methods are 2 innovating spectrophotometric methods used to determine vincamine in the presence of its acid degradation product and a mixture of cinnarizine (CN) and nicergoline (NIC). Linear correlations were obtained i... |
|
|
Wakayama symposium: new therapies for modulation of epithelialization in corneal wound healing.
Ocul. Surf. 11(1) , 16-8, (2013) Many factors are involved in the corneal wound healing mechanism, including adhesion, migration, and proliferation of corneal epithelial cells. Abnormal corneal wound healing leads to corneal edema, neovascularization, scar formation, and poor vision. Three a... |
|
|
Nicergoline improves dysphagia by upregulating substance P in the elderly.
Medicine (Baltimore.) 90(4) , 279-83, (2011) Dysphagia induces silent aspiration, which is a known risk factor for aspiration pneumonia in the elderly. Dysphagia is associated with impaired substance P secretion. Because nicergoline was recently reported to enhance substance P secretion, it may improve ... |
|
|
Effects of nicergoline on corneal epithelial wound healing in rat eyes.
Invest. Ophthalmol. Vis. Sci. 50(2) , 621-5, (2009) To investigate the effect of nicergoline on corneal epithelial wound healing in rats.One hundred Sprague-Dawley male rats were divided into two groups, the control group and the nicergoline-treated group, for 2 weeks. Corneal wound healing was evaluated by fl... |
|
|
Second-derivative synchronous fluorescence spectroscopy for the simultaneous determination of cinnarizine and nicergoline in pharmaceutical preparations.
J. AOAC Int. 91(2) , 349-59, (2008) A rapid, simple, and highly sensitive second-derivative synchronous fluorometric method has been developed for the simultaneous analysis of binary mixtures of cinnarizine (CN) and nicergoline (NIC). The method is based upon measurement of the native fluoresce... |
|
|
Nicergoline increases serum substance P levels in patients with an ischaemic stroke.
Cerebrovasc. Dis. 29(2) , 194-8, (2010) Aspiration pneumonia is one of the most important complications following ischaemic stroke, and a leading cause of mortality in stroke patients. This is particularly prevalent in patients with involvement of the basal ganglia, which may be due to impaired neu... |
|
|
Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.
Brain Res. 1047(1) , 30-7, (2005) Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against beta-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of beta-amy... |