Clemizole hydrochloride
Clemizole hydrochloride structure
|
Common Name | Clemizole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1163-36-6 | Molecular Weight | 362.296 | |
| Density | 1.25 g/cm3 | Boiling Point | 506.1ºC at 760 mmHg | |
| Molecular Formula | C19H21Cl2N3 | Melting Point | 241 °C | |
| MSDS | Chinese USA | Flash Point | 259.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Mol. Pharmacol. 86(5) , 514-21, (2014) Canonical transient receptor potential channel 5 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belongs to the large family of transient receptor potential channels. It is predominantly found in the central nervous system with a high expressi... |
|
|
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Nat. Commun. 4 , 2410, (2013) Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Nav1.1 (SCN1A), a voltage-gated sodium channel. ... |
|
|
Clemizole hydrochloride. Parvez M
Acta Crystallogr. C Struct. Chem. 52(4) , 904-905, (1996)
|