C75
C75 structure
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Common Name | C75 | ||
|---|---|---|---|---|
| CAS Number | 218137-86-1 | Molecular Weight | 254.322 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 432.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H22O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 159.2±22.2 °C | |
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Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Biochem. J. 469 , 189-98, (2015) NAD(+) plays essential roles in cellular energy homoeostasis and redox state, functioning as a cofactor along the glycolysis and citric acid cycle pathways. Recent discoveries indicated that, through the NAD(+)-consuming enzymes, this molecule may also be inv... |
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Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
PLoS ONE 3(6) , e2329, (2008) DNA damage triggers a network of signaling events that leads to cell cycle arrest or apoptosis. This DNA damage response acts as a mechanism to prevent cancer development. It has been reported that fatty acids (FAs) synthesis is increased in many human tumors... |
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EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.
Sci. Signal. 2 , ra82, (2010) Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma, their clinical relevance is poorly understood. Studies of tu... |
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Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Radiat. Res. 184 , 482-93, (2015) Many common human cancers, including colon, prostate and breast cancer, express high levels of fatty acid synthase compared to normal human tissues. This elevated expression is associated with protection against apoptosis, increased metastasis and poor progno... |
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Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis.
Cardiovasc. Res. 107 , 78-88, (2015) Viral myocarditis (VM) is severe cardiac inflammation that can result in sudden death or congestive heart failure in previously healthy adults, with no effective therapy. Liver X receptor (LXR) agonists have both anti-inflammatory and lipid-lowering propertie... |
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Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
PLoS ONE 7 , e41094, (2012) Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein synthesis machineries. Relaxation of the circular, double-stranded mtDNA relies on the presence of topoisomerase activity. Three different topoisomerases have b... |
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Different fatty acid metabolism effects of (-)-epigallocatechin-3-gallate and C75 in adenocarcinoma lung cancer.
BMC Cancer 12 , 280, (2012) Fatty acid synthase (FASN) is overexpressed and hyperactivated in several human carcinomas, including lung cancer. We characterize and compare the anti-cancer effects of the FASN inhibitors C75 and (-)-epigallocatechin-3-gallate (EGCG) in a lung cancer model.... |
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Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype.
Br. J. Cancer 102 , 1736-45, (2010) We aimed to clarify the incidence and the clinicopathological value of non-muscle myoglobin (Mb) in a large cohort of non-invasive and invasive breast cancer cases.Matched pairs of breast tissues from 10 patients plus 17 breast cell lines were screened by qua... |
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p63 promotes cell survival through fatty acid synthase.
PLoS ONE 4 , e5877, (2009) There is increasing evidence that p63, and specifically DeltaNp63, plays a central role in both development and tumorigenesis by promoting epithelial cell survival. However, few studies have addressed the molecular mechanisms through which such important func... |
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Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation.
PLoS ONE 8 , e77845, (2013) Voluntary running is a robust inducer of adult hippocampal neurogenesis. Given that fatty acid synthase (FASN), the key enzyme for de novo fatty acid biosynthesis, is critically involved in proliferation of embryonic and adult neural stem cells, we hypothesiz... |