S-(+)-Ketoprofen
S-(+)-Ketoprofen structure
|
Common Name | S-(+)-Ketoprofen | ||
|---|---|---|---|---|
| CAS Number | 22161-81-5 | Molecular Weight | 254.281 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 431.3±28.0 °C at 760 mmHg | |
| Molecular Formula | C16H14O3 | Melting Point | 75-78ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 228.8±20.5 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
|
Hologram QSAR model for the prediction of human oral bioavailability.
Bioorg. Med. Chem. 15 , 7738-45, (2007) A drug intended for use in humans should have an ideal balance of pharmacokinetics and safety, as well as potency and selectivity. Unfavorable pharmacokinetics can negatively affect the clinical development of many otherwise promising drug candidates. A varie... |
|
|
2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
J. Med. Chem. 48 , 4312-31, (2005) The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR... |
|
|
Scope of partial least-squares regression applied to the enantiomeric composition determination of ketoprofen from strongly overlapped chromatographic profiles.
J. Sep. Sci. 38 , 2423-30, (2015) Valuable quantitative information could be obtained from strongly overlapped chromatographic profiles of two enantiomers by using proper chemometric methods. Complete separation profiles where the peaks are fully resolved are difficult to achieve in chiral se... |
|
|
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
J. Med. Chem. 52 , 4277, (2009) We report novel inhibitors of Gli1-mediated transcription as potential anticancer agents. Focused chemical libraries were designed and assessed for inhibition of functional cell-based Gli1-mediated transcription and selective toxicity toward cancer cells. The... |