CCCP
CCCP structure
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Common Name | CCCP | ||
|---|---|---|---|---|
| CAS Number | 555-60-2 | Molecular Weight | 204.61600 | |
| Density | 1.26 g/cm3 | Boiling Point | 318.3ºC at 760 mmHg | |
| Molecular Formula | C9H5ClN4 | Melting Point | 170-175 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | 146.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation.
Pigment Cell Melanoma Res. 27(6) , 1051-62, (2014) Mitochondrial dynamics control mitochondrial functions as well as their morphology. However, the role of mitochondrial dynamics in melanogenesis is largely unknown. Here, we show that mitochondrial dynamics regulate melanogenesis by modulating the ROS-ERK sig... |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
PLoS ONE 9(11) , e112413, (2014) Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number v... |
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Lactic acid is a sperm motility inactivation factor in the sperm storage tubules.
Sci. Rep. 5 , 17643, (2015) Although successful fertilization depends on timely encounters between sperm and egg, the decoupling of mating and fertilization often confers reproductive advantages to internally fertilizing animals. In several vertebrate groups, postcopulatory sperm viabil... |
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
EMBO Rep. 16 , 939-54, (2015) Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser(65)... |
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Genes associated with sodium fluoride-induced human osteoblast apoptosis.
Int. J. Clin. Exp. Med. 8 , 13171-8, (2015) This study aims to explore the potential pathways and molecular characteristics of fluorine-induced osteoblast apoptosis. In vitro fluorine-induced model was established with an osteogenesis sarcoma cell line Saos-2. Then flow cytometry was used to determine ... |
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Mechanisms involved in quinolone resistance in Mycoplasma mycoides subsp. capri.
Vet. J. 204 , 327-32, (2015) Mycoplasma mycoides subsp. capri is a causative agent of contagious agalactia in goats. In this study, M. mycoides subsp. capri mutants were selected for resistance to fluoroquinolones (norfloxacin, enrofloxacin and ciprofloxacin) by serial passes in broth wi... |
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Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice.
Toxicol. Appl. Pharmacol. 279(3) , 391-400, (2014) Methamidophos (MET) is a highly toxic organophosphate (OP) pesticide that is widely used in developing countries. MET has male reproductive effects, including decreased fertility. We evaluated MET effects on sperm quality, fertilization and DNA integrity, exp... |
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Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death.
Cancer Res. 75 , 2478-88, (2015) Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid derived from avocado fruit, as a novel compound with cytotoxic activity in AML. Avocat... |
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NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction.
Pestic. Biochem. Physiol. 123 , 74-86, (2015) Oxidative stress is a key factor in Parkinson's disease (PD) pathogenesis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and impaired mitochondrion regulate oxidative stress-mediated maneb (MB)- and paraquat (PQ)-induced Parkinsonism. However, t... |