Eosin Y

Eosin Y Structure
Eosin Y structure
Common Name Eosin Y
CAS Number 15086-94-9 Molecular Weight 691.854
Density 1.02 g/mL at 20ºC Boiling Point 640.3ºC at 760 mmHg
Molecular Formula C20H8Br4O5 Melting Point 295ºC
MSDS Chinese USA Flash Point N/A

PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.

Gastroenterology 147(6) , 1405-16.e7, (2014)

New drug targets are urgently needed for the treatment of patients with pancreatic ductal adenocarcinoma (PDA). Nearly all PDAs contain oncogenic mutations in the KRAS gene. Pharmacological inhibition of KRAS has been unsuccessful, leading to a focus on downs...

Chondrogenesis of human bone marrow mesenchymal stromal cells in highly porous alginate-foams supplemented with chondroitin sulfate.

Mater. Sci. Eng. C. Mater. Biol. Appl. 50 , 160-72, (2015)

To overcome the limited intrinsic cartilage repair, autologous chondrocyte or bone-marrow-derived mesenchymal stromal cell (BM-MSC) was implanted into cartilage defects. For this purpose suitable biocompatible scaffolds are needed to provide cell retention, c...

Enhanced antitumor effects of the BRBP1 compound peptide BRBP1-TAT-KLA on human brain metastatic breast cancer.

Sci. Rep. 5 , 8029, (2015)

Novel molecularly targeted agents that block the development and metastasis of human brain metastatic breast cancer hold great promise for their translational value. In this study, we constructed a novel targeting composite peptide BRBP1-TAT-KLA comprising of...

Induction of DNA damage and G2 cell cycle arrest by diepoxybutane through the activation of the Chk1-dependent pathway in mouse germ cells.

Chem. Res. Toxicol. 28(3) , 518-31, (2015)

1,2:3,4-Diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown to cause DNA strand breaks in cells through its potential genotoxicity. The adverse effect of DEB on male reproductive cells in response to DNA damage h...

CKD-516 displays vascular disrupting properties and enhances anti-tumor activity in combination with chemotherapy in a murine tumor model.

Invest. New Drugs 32(3) , 400-11, (2014)

CKD-516 is a benzophenone analog in which the B ring is modified by replacement with a carbonyl group. The study assessed CKD-516 as a vascular disrupting agent or anti-cancer drug.To assess the effect of S516 on vascularization, we analyzed the effect on hum...

Rapid mapping of insertional mutations to probe cell wall regulation in Cryptococcus neoformans.

Fungal Genet. Biol. 82 , 9-21, (2015)

Random insertional mutagenesis screens are important tools in microbial genetics studies. Investigators in fungal systems have used the plant pathogen Agrobacterium tumefaciens to create tagged, random mutations for genetic screens in their fungal species of ...

Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network.

J. Cell Biol. 208(3) , 331-50, (2015)

Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities and the matrix itself in dynamic, bidirectional processes. One such process is local proteolytic modification of the ECM. Invadopodia of tumor cells are actin-rich...

Percentage exposure of root dentin collagen after application of two irrigation protocols with manual or rotary instrumentation and two methacrylate resin-based sealers.

J. Adhes. Dent. 15(5) , 481-9, (2013)

To compare the percentage of collagen exposed in dentin root thirds after two irrigation protocols with manual or rotary instrumentation using two methacrylate resin-based sealers.Forty-eight single-root human teeth were prepared with manual (n = 24) or nicke...

SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis.

J. Immunol. 194(6) , 2796-809, (2015)

Virus-induced myositis is an emerging global affliction that remains poorly characterized with few treatment options. Moreover, muscle-tropic viruses often spread to the CNS, causing dramatically increased morbidity. Therefore, there is an urgent need to expl...

Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds.

Tissue Eng. Part A 21(5-6) , 970-81, (2015)

Our long-term goal is to develop smart biomaterials that can facilitate regeneration of critical-size craniofacial lesions. In this study, we tested the hypothesis that biomimetic scaffolds electrospun from chitosan (CTS) will promote tissue repair and regene...