Ascomycin
Ascomycin structure
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Common Name | Ascomycin | ||
|---|---|---|---|---|
| CAS Number | 104987-12-4 | Molecular Weight | 792.008 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 868.3±75.0 °C at 760 mmHg | |
| Molecular Formula | C43H69NO12 | Melting Point | 153-157ºC | |
| MSDS | Chinese USA | Flash Point | 478.9±37.1 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Highly specific targeting of human leukocytes using gold nanoparticle-based biologically active conjugates.
J. Biomed. Nanotechnol. 10(7) , 1259-66, (2014) In this study we demonstrate for the first time a new approach for highly specific targeting of viable human leukocytes by functionalised gold nanoconjugates made on the basis of citrate-stabilised gold nanoparticles. This immobilisation involves highly speci... |
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Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.
Clin. Exp. Allergy 35(5) , 554-9, (2005) Chronic urticaria is a common skin disorder, which causes considerable morbidity. In approximately 40% of cases, patients have an autoimmune disorder in which functional antibodies cause degranulation of mast cells and basophils, and C5a complement augments t... |
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The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding.
J. Immunol. 177(10) , 7050-8, (2006) Cyclosporin A (CsA) is a fungus-derived cyclic undecapeptide with potent immunosuppressive activity. Its analog, cyclosporin H (CsH), lacks immunosuppressive function but can act as an antagonist for the human formyl peptide receptor (FPR). More recent studie... |
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Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method.
Biomed. Chromatogr. 24(4) , 399-405, (2010) A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and validated for determining tacrolimus (FK506) in rat tissues to study the effect of Schisandra sphenanthera extract on FK506 tissue distribution. After a liquid-liquid extract... |
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An adaptable luminescence resonance energy transfer assay for measuring and screening protein-protein interactions and their inhibition.
ChemBioChem. 13(4) , 553-8, 489, (2012) Protein-protein interactions (PPIs) are central to biological processes and represent an important class of therapeutic targets. Here we show that the interaction between FK506-binding protein 12 fused to green fluorescent protein (GFP-FKBP) and the rapamycin... |
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Procedure for chromatography involving sample solvent with higher elution strength than the mobile phase.
J. Chromatogr. A. 1177(2) , 234-42, (2008) In preparative chromatography, often the solubility of the sample in the mobile phase is limited, making the mobile phase unsuitable as a solvent for preparation of load. Generally, solvents that have high solubility for the sample also have higher elution st... |
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Evaluation, synthesis and characterization of tacrolimus impurities.
J. Antibiot. 65(7) , 349-54, (2012) Tacrolimus is an immunosuppressant macrolactam of fermentative origin. By means of HPLC, LC-MS and NMR analyses, coupled with the reference standard synthesis, the main impurities of tacrolimus bulk drug samples were identified and their chemical-physical pro... |
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Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.
Pharmacol. Biochem. Behav. 84(3) , 511-6, (2006) The potential in vivo anticonvulsant effect of calcineurin (protein phosphatase 2B) inhibitor ascomycin against seizures induced by intrahippocampal microdialysis of picrotoxin was examined in the present study. After establishing individual picrotoxin seizur... |
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Calcineurin activation by slow calcium release from intracellular stores suppresses protein kinase C regulation of L-type calcium channels in L6 cells
Cell Calcium 46(4) , 242-7, (2009) L-type Ca 2+ channel activity was assayed in L6 cells as the rate of nifedipine-sensitive Ba 2+ influx in a depolarizing medium. In the absence of extracellular Ca 2+, activation of protein kinase C (PKC) with phorbol-12-myristate-13-acetate (PMA) or thymelea... |
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Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair.
J. Mol. Histol. 37(5-7) , 285-91, (2006) Calcineurin inhibitors are drugs used to suppress the immune system by blocking the nuclear localization of the NFAT transcription factor. Systemic use of these drugs is essential to organ transplantation, but comes at the cost of elevated rates of skin cance... |