Fipexide
Fipexide structure
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Common Name | Fipexide | ||
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| CAS Number | 34161-24-5 | Molecular Weight | 388.84500 | |
| Density | 1.342g/cm3 | Boiling Point | 559.3ºC at 760mmHg | |
| Molecular Formula | C20H21ClN2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 292.1ºC | |
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Effect of fipexide on passive avoidance behaviour in rats.
Pharmacol. Res. 21(5) , 603-8, (1989) The effect of fipexide, administered at different intervals after the learning trial of a single step-through type passive avoidance situation was studied. The administration of fipexide immediately after the learning trial resulted in a long-lasting facilita... |
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[Fever caused by fipexide. Evaluation of the national pharmacovigilance survey].
Therapie. 45(5) , 429-31, (1990) Fourteen cases of drug fever due to fipexide were reported by a retrospective survey of a National Network of French Pharmacovigilance. 8 women, 6 men (mean age, 52 years), presented a sudden fever with a mean onset delay of 7 days after the first cure (range... |
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[Fever after taking fipexide hydrochloride].
Presse Med. 18(21) , 1076, (1989)
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[Acute drug-induced hepatitis: a case of acute cytolysis after ingestion of fipexide].
Gastroenterol. Clin. Biol. 14(5) , 513-4, (1990)
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Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats.
Eur. Neuropsychopharmacol. 6 , 285, (1996) Deficit in active and inhibitory avoidance behaviour has been pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy. In the present study we examined the effect of the nootropic drugs piracetam and f... |
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Investigating the in vitro metabolism of fipexide: characterization of reactive metabolites using liquid chromatography/mass spectrometry.
Rapid Commun. Mass Spectrom. 21(14) , 2301-11, (2007) The in vitro metabolism of the nootropic drug fipexide was studied using different liquid chromatography/mass spectrometry (LC/MS) techniques. This drug has been withdrawn from the market due to toxic effects. No previous reports have investigated the possibl... |
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[Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level].
Boll. Chim. Farm. 122(2) , 79-85, (1983)
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Influence of nootropic drugs on the memory-impairing effect of diethyldithiocarbamate and clonidine in "step down" passive avoidance in albino rats.
Acta Physiol. Pharmacol. Bulg. 14(4) , 36-41, (1988) Experiments on albino rats were carried out to study the effects of the nootropic drugs piracetam, aniracetam, meclofenoxate and fipexide on the DA-beta-hydroxylase inhibitor diethyldithiocarbamate- and the alpha 2-adrenoceptor agonist clonidine-impaired cogn... |
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Determining protein adducts of fipexide: mass spectrometry based assay for confirming the involvement of its reactive metabolite in covalent binding.
Rapid Commun. Mass Spectrom. 21(24) , 4149-57, (2007) Fipexide is a nootropic drug, withdrawn from the market due to its idiosyncratic drug reactions causing adverse effects in man. Previous work on its metabolites has identified several potential reactive metabolites which could be implicated in protein binding... |
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Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.
Rapid Commun. Mass Spectrom. 24(9) , 1241-50, (2010) Drug bioactivation leading to the formation of reactive species capable of covalent binding to proteins represents an important cause of drug-induced toxicity. Reactive metabolite detection using in vitro microsomal incubations is a crucial step in assessing ... |