PENTOSTATIN

PENTOSTATIN Structure
PENTOSTATIN structure
Common Name PENTOSTATIN
CAS Number 53910-25-1 Molecular Weight 268.269
Density 1.8±0.1 g/cm3 Boiling Point 673.1±65.0 °C at 760 mmHg
Molecular Formula C11H16N4O4 Melting Point 220-225ºC
MSDS Chinese USA Flash Point 360.9±34.3 °C
Symbol GHS06
GHS06
Signal Word Danger

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.

Arch. Toxicol. 89(1) , 107-19, (2015)

The use of diclofenac (DCF), a nonsteroidal anti-inflammatory drug, is associated with a high prevalence of gastrointestinal side effects. In vivo studies in rodents suggested that reactive metabolites of DCF produced by the liver or the intestine might be re...

Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.

PLoS ONE 9(11) , e112130, (2014)

To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear. Mitochondrial chaperones regulate mitochondrial function and structure. Chaperon...

The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents.

Int. J. Oncol. 46(2) , 667-76, (2014)

The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated that HMGB1 induces a distinct, necrosis-like cell death in...

Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial injury across species.

PLoS ONE 10(4) , e0122275, (2015)

The effects of Corexit 9500A (CE) on respiratory epithelial surfaces of terrestrial mammals and marine animals are largely unknown. This study investigated the role of CE-induced heme oxygenase-1 (HO-1), a cytoprotective enzyme with anti-apoptotic and antioxi...

The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages.

Int. J. Nanomedicine 10 , 821-38, (2015)

To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism.CCK-8 was used to examine cell viability. Confocal laser scanning microscopy was performed to assess the localization of ...

Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.

J. Cell. Biochem. 116 , 1553-62, (2015)

Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections....

In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells.

PLoS ONE 10 , e0134768, (2015)

Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the antioxidant resveratrol (RSV) on DDS hydroxylamine (DDS-NHO...

Permanganate oxidation of diclofenac: The pH-dependent reaction kinetics and a ring-opening mechanism.

Chemosphere 136 , 297-304, (2015)

In this work, the fate of diclofenac (DCF) during permanganate (Mn(VII)) oxidation was investigated at environmentally relevant pH conditions (from 5 to 9). The batch experiments showed that the kinetics of the Mn(VII)/DCF reaction follows a second-order rate...

Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells.

Anticancer Res. 35(1) , 85-96, (2015)

Cancer stem cells (CSCs) are considered to contribute to the poor prognosis of ovarian cancer as a major cause of fatal recurrence. Identification of effective measures to eliminate ovarian CSCs through induction of cell death and/or loss of self-renewal capa...

Apolipoprotein A-I mimetic peptide reverses impaired arterial healing after injury by reducing oxidative stress.

Atherosclerosis 241 , 709-15, (2015)

Endothelial cell (EC) migration is essential for healing of arterial injuries caused by angioplasty, but a high cholesterol diet inhibits endothelial repair. In vivo studies suggest that apolipoprotein A-I (apoA-I), the major protein constituent of HDL, is es...