![]() PENTOSTATIN structure
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Common Name | PENTOSTATIN | ||
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CAS Number | 53910-25-1 | Molecular Weight | 268.269 | |
Density | 1.8±0.1 g/cm3 | Boiling Point | 673.1±65.0 °C at 760 mmHg | |
Molecular Formula | C11H16N4O4 | Melting Point | 220-225ºC | |
MSDS | Chinese USA | Flash Point | 360.9±34.3 °C | |
Symbol |
![]() GHS06 |
Signal Word | Danger |
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.
Arch. Toxicol. 89(1) , 107-19, (2015) The use of diclofenac (DCF), a nonsteroidal anti-inflammatory drug, is associated with a high prevalence of gastrointestinal side effects. In vivo studies in rodents suggested that reactive metabolites of DCF produced by the liver or the intestine might be re... |
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Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.
PLoS ONE 9(11) , e112130, (2014) To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear. Mitochondrial chaperones regulate mitochondrial function and structure. Chaperon... |
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The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents.
Int. J. Oncol. 46(2) , 667-76, (2014) The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated that HMGB1 induces a distinct, necrosis-like cell death in... |
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Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial injury across species.
PLoS ONE 10(4) , e0122275, (2015) The effects of Corexit 9500A (CE) on respiratory epithelial surfaces of terrestrial mammals and marine animals are largely unknown. This study investigated the role of CE-induced heme oxygenase-1 (HO-1), a cytoprotective enzyme with anti-apoptotic and antioxi... |
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The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages.
Int. J. Nanomedicine 10 , 821-38, (2015) To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism.CCK-8 was used to examine cell viability. Confocal laser scanning microscopy was performed to assess the localization of ... |
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Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.
J. Cell. Biochem. 116 , 1553-62, (2015) Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections.... |
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In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells.
PLoS ONE 10 , e0134768, (2015) Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the antioxidant resveratrol (RSV) on DDS hydroxylamine (DDS-NHO... |
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Permanganate oxidation of diclofenac: The pH-dependent reaction kinetics and a ring-opening mechanism.
Chemosphere 136 , 297-304, (2015) In this work, the fate of diclofenac (DCF) during permanganate (Mn(VII)) oxidation was investigated at environmentally relevant pH conditions (from 5 to 9). The batch experiments showed that the kinetics of the Mn(VII)/DCF reaction follows a second-order rate... |
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Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells.
Anticancer Res. 35(1) , 85-96, (2015) Cancer stem cells (CSCs) are considered to contribute to the poor prognosis of ovarian cancer as a major cause of fatal recurrence. Identification of effective measures to eliminate ovarian CSCs through induction of cell death and/or loss of self-renewal capa... |
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Apolipoprotein A-I mimetic peptide reverses impaired arterial healing after injury by reducing oxidative stress.
Atherosclerosis 241 , 709-15, (2015) Endothelial cell (EC) migration is essential for healing of arterial injuries caused by angioplasty, but a high cholesterol diet inhibits endothelial repair. In vivo studies suggest that apolipoprotein A-I (apoA-I), the major protein constituent of HDL, is es... |