Dexamethasone-17-acetate
Dexamethasone-17-acetate structure
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Common Name | Dexamethasone-17-acetate | ||
|---|---|---|---|---|
| CAS Number | 1177-87-3 | Molecular Weight | 434.498 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 579.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H31FO6 | Melting Point | 238-240 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 304.2±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Upregulation of nucleoside triphosphate diphosphohydrolase-1 and ecto-5'-nucleotidase in rat hippocampus after repeated low-dose dexamethasone administration.
J. Mol. Neurosci. 55(4) , 959-67, (2015) Although dexamethasone (DEX), a synthetic glucocorticoid receptor (GR) analog with profound effects on energy metabolism, immune system, and hypothalamic-pituitary-adrenal axis, is widely used therapeutically, its impact on the brain is poorly understood. The... |
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Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes.
Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012 , 681-4, (2012) This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated... |
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Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system.
Eur. J. Pharm. Biopharm. 93 , 110-7, (2015) In the treatment of arthritic diseases, oral or systemic administration of anti-inflammatory substances, such as p38 MAPK inhibitors, is hampered by numerous side effects. To overcome them, formulations of rapid and extended drug delivery systems were studied... |
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[Preparation and applications of a supported liquid-liquid extraction column with a composite diatomite material].
Se Pu 30(8) , 798-803, (2012) A rapid and special supported liquid-liquid extraction (SLE) column was developed with a composite diatomite material. The SLE column was evaluated by high performance liquid chromatography (HPLC) with acidic, neutral and alkaline compounds dissolved in water... |
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PET imaging of disease progression and treatment effects in the experimental autoimmune encephalomyelitis rat model.
J. Nucl. Med. 55(8) , 1330-5, (2015) The experimental autoimmune encephalomyelitis model is a model of multiple sclerosis that closely mimics the disease characteristics in humans. The main hallmarks of multiple sclerosis are neuroinflammation (microglia activation, monocyte invasion, and T-cell... |
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Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles.
Arch. Pharm. Res. 30(4) , 519-25, (2007) The objective of the present study was to develop a novel solid lipid nanoparticle (SLN) for the lung-targeting delivery of dexamethasone acetate (DXM) by intravenous administration. DXM loaded SLN colloidal suspensions were prepared by the high pressure homo... |
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Local drug delivery system: inhibition of inflammatory angiogenesis in a murine sponge model by dexamethasone-loaded polyurethane implants.
J. Pharm. Sci. 100(7) , 2886-95, (2011) Implants are defined as controlled sustained release delivery systems of therapeutic agents incorporated or dispersed into a polymeric carrier. These systems can be implanted in specific organs and delivered by the therapeutic agents at the target site to tre... |
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Inhibitory efficacy of intravitreal dexamethasone acetate-loaded PLGA nanoparticles on choroidal neovascularization in a laser-induced rat model.
J. Ocul. Pharmacol. Ther. 23(6) , 527-40, (2007) The aims of this study were to investigate the inhibitory efficacy of intravitreal dexamethasone acetate (DA)-loaded by (D, L-lactide-co-glycolide) (PLGA) nanoparticles on choroidal neovascularization (CNV) in a laser-induced rat model and to evaluate its mod... |
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Controlled release of dexamethasone acetate from biodegradable and biocompatible polyurethane and polyurethane nanocomposite.
J. Drug Target. 17(5) , 374-83, (2009) Polyurethanes and polyurethane nanocomposites can be applied to control the release of drugs previously incorporated into these materials. In this study, dexamethasone acetate (ACT) was incorporated into biodegradable and biocompatible polyurethane and polyur... |
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Anti-inflammatory activity of injectable dexamethasone acetate-loaded nanostructured lipid carriers.
Drug Deliv. 18(7) , 485-92, (2011) This work studied the intravenous injection formulation of nanostructured lipid carriers (NLCs) loaded with dexamethasone acetate (DA), a poorly water-soluble drug. The goal of this study was to design nanoparticles which could improve therapeutic efficacy of... |