Dynorphin A (1-13)
Dynorphin A (1-13) structure
|
Common Name | Dynorphin A (1-13) | ||
|---|---|---|---|---|
| CAS Number | 72957-38-1 | Molecular Weight | 1603.955 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C75H126N24O15 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.
J. Med. Chem. 43(7) , 1251-2, (2000)
|
|
|
Central reinforcing effects of ethanol are blocked by catalase inhibition.
Alcohol 41(7) , 525-34, (2007) Recent studies have systematically indicated that newborn rats are highly sensitive to ethanol's positive reinforcing effects. Central administrations of ethanol (25-200mg %) associated with an olfactory conditioned stimulus (CS) promote subsequent conditione... |
|
|
Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat.
Neurosci. Res. 54(1) , 49-56, (2006) Our previous study proved that the hypothalamic paraventricular nucleus (PVH) plays an important role in acupuncture analgesia. The neuropeptides involving in the PVH regulation of acupuncture analgesia was investigated in the rat. The changes of pain thresho... |
|
|
Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development.
Life Sci. 73(6) , 749-58, (2003) Although dynorphin has long been considered an endogenous opioid peptide with high affinity for the kappa-opioid receptor, its biological function remains uncertain. The high concentration of dynorphin peptides and kappa-opioid receptors in the hypothalamus s... |
|
|
Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats.
Life Sci. 78(21) , 2516-22, (2006) To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) in pulmonary artery in the rat.Isolated pulmonary artery ring was perfused and the tension of the vessel was measured.U50,488H relaxed the pu... |
|
|
Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus.
Neurosci. Lett. 331(2) , 123-7, (2002) We compared the anticonvulsant actions of dynorphin A (1-13), galanin, neuropeptide Y and somatostatin in a model of self-sustaining status epilepticus (SSSE). SSSE was induced in adult Wistar rats by 30 min intermittent perforant path stimulation. Peptides o... |
|
|
Effects of microiontophoretically-applied opioid peptides on Purkinje cells in the cat cerebellum.
Acta Pharmacol. Sin. 21(10) , 877-84, (2000) The purpose of the present study was to examine the effects of microiontophoretically-applied opioid peptides on Purkinje cell of the cerebellum.The effects of microiontophoretically-applied morphine, leucine-enkephalin (Leu-Enk), methionine-enkephalin (Met-E... |
|
|
Lack of tolerance and morphine-induced cross-tolerance to the analgesia of chimeric peptide of Met-enkephalin and FMRFa.
Peptides 29(12) , 2266-75, (2008) Chimeric peptide of Met-enkephalin and FMRFa (YGGFMKKKFMRFa-YFa), a kappa-opioid receptor specific peptide, did not induce tolerance and cross-tolerance effects to its analgesic action on day 5 after pretreatment with either YFa or morphine for 4 days. Howeve... |
|
|
New tris-alkoxycarbonyl arginine derivatives for peptide synthesis.
J. Pept. Sci. 11(1) , 60-4, (2005) alpha-Alkoxycarbonyl protected ornithines were treated with N,N'-[Z(2Cl)](2)-S-methylisothiourea and N,N'-[Z(2Br)](2)-S-methylisothiourea, N,N'-Z(2)-S-methylisothiourea and N,N'-Boc(2)-S-methylisothiourea to form N(alpha, omega, omega')-tris-alkoxycarbonyl ar... |
|
|
Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1-13.
Cell. Mol. Neurobiol. 27(1) , 1-10, (2007) This study was designed to investigate the effect of acute and chronic high-intensity treadmill exercise on changes in plasma lactate and brain neuropeptide (NPY), leucine-enkephalin (L-ENK), and dynorphin A(1-13) (DYN A(1-13)). Avidin-biotin complex (ABC) im... |