Dehydroleucodine
Dehydroleucodine structure
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Common Name | Dehydroleucodine | ||
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| CAS Number | 36150-07-9 | Molecular Weight | 244.28600 | |
| Density | 1.2g/cm3 | Boiling Point | 450.6ºC at 760mmHg | |
| Molecular Formula | C15H16O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 203.1ºC | |
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Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.
Fitoterapia 79(1) , 1-5, (2008) Dehydroleucodine (DhL), a sesquiterpene lactone obtained from Artemisia douglasiana, was screened for antidiarrheal effects. DhL inhibited castor oil-induced diarrhea in mice by judged by a decrease in the number of wet faeces in the DhL-treatment groups. DhL... |
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Role of mast cells in gastrointestinal mucosal defense.
Biocell 27(2) , 163-72, (2003) The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with gastrointestinal mucosal defense. Gastrointestinal mast cells are invo... |
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Effect of dehydroleucodine on intestinal transit: structural basis of the interaction with the α(2)-adrenergic receptor.
Eur. Biophys. J. 40(8) , 981-6, (2011) The activity of dehydroleucodine, a sesquiterpene lactone obtained from Artemisia douglasiana, was studied in mice small intestinal transit. Its mechanism was evaluated in the presence of several adrenergic and cholinergic antagonist drugs and one opioid anta... |
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The sesquiterpene lactone dehydroleucodine reversibly inhibits Allium cepa L. root growth.
Biocell 25(1) , 29-34, (2001) Here, we prove that dehydroleucodine, a sesquiterpene lactone, at low concentrations (25-100 microM) slowed down the Allium cepa L root growth by 22-70% respectively neither affecting cell viability nor cell size. Removal of the drug after 24 h incubation res... |
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Effect of dehydroleucodine on meiosis reinitiation in Bufo arenarum denuded oocytes.
Zygote 15(2) , 183-7, (2007) In amphibian oocytes meiosis, the transition from G2 to M phase is regulated by the maturation promoting factor (MPF), a complex of the cyclin-dependent kinase p34/cdc2 and cyclin B. In immature oocytes there is an inactive complex (pre-MPF), in which cdc2 is... |
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Effect of dehydroleucodine on histamine and serotonin release from mast cells in the isolated mouse jejunum.
Inflamm. Res. 52(5) , 199-205, (2003) DhL, a lactone isolated from Artemisia douglasiana, prevents gastrointestinal damage elicited by necrosis-inducing agents and exhibits antiinflammatory action. This work examines the effect of DhL on compound 48/80-induced histamine and serotonin release in t... |
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Effect of dehydroleucodine on the reproductive tract of male mice.
Andrologie 43(5) , 297-302, (2011) The effects of a sesquiterpene lactone, dehydroleucodine, on the reproductive tract were investigated using adult male mice. Dehydroleucodine was dissolved in tap water and administered as drinking water for 30 days. All the parameters were compared with a co... |
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Dehydroleucodine inhibits vascular smooth muscle cell proliferation in G2 phase.
Cell Mol. Biol. 51(6) , 525-30, (2005) Vascular smooth muscle cell (VSMC) proliferation plays an important role in the development of atherosclerosis and in the vascular changes seen in hypertension. Dehydroleucodine (DhL) is a sesquiterpene lactone that inhibits cell proliferation in plant cells.... |
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Production of IVF transgene-expressing bovine embryos using a novel strategy based on cell cycle inhibitors.
Theriogenology 78(1) , 57-68, (2012) The objective was to evaluate the effects of cell cycle inhibitors (6-dimethylaminopurine [DMAP], and dehydroleukodine [DhL]) on transgene expression efficiency and on mosaic expression patterns of IVF bovine zygotes cytoplasmically injected with oolema vesic... |
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Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana.
J. Ethnopharmacol. 88(2-3) , 195-8, (2003) The effect of Dehydroleucodine (DhL) on gastric acid secretion in rats was investigated at a dose of 40 mg/kg, while its anti-inflammatory effect was investigated in two experimental models: arthritis induced by Freund's adjuvant carrageenan- and cotton pelle... |