All-trans-retinal
All-trans-retinal structure
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Common Name | All-trans-retinal | ||
|---|---|---|---|---|
| CAS Number | 116-31-4 | Molecular Weight | 284.436 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 421.4±14.0 °C at 760 mmHg | |
| Molecular Formula | C20H28O | Melting Point | 61-63°C | |
| MSDS | Chinese USA | Flash Point | 205.4±12.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans.
Anal. Biochem. 472 , 30-6, (2015) High-resolution structural determination and dynamic characterization of membrane proteins by nuclear magnetic resonance (NMR) require their isotopic labeling. Although a number of labeled eukaryotic membrane proteins have been successfully expressed in bacte... |
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The Activation Pathway of Human Rhodopsin in Comparison to Bovine Rhodopsin.
J. Biol. Chem. 290 , 20117-27, (2015) Rhodopsin, the photoreceptor of rod cells, absorbs light to mediate the first step of vision by activating the G protein transducin (Gt). Several human diseases, such as retinitis pigmentosa or congenital night blindness, are linked to rhodopsin malfunctions.... |
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Quantitation of retinaldehyde in small biological samples using ultrahigh-performance liquid chromatography tandem mass spectrometry.
Anal. Biochem. 484 , 162-8, (2015) We report an ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method to quantify all-trans-retinal in biological samples of limited size (15-35mg), which is especially advantageous for use with adipose. To facilitate recovery... |
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Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons.
Nat. Commun. 5 , 4894, (2014) Probing the neural circuit dynamics underlying behaviour would benefit greatly from improved genetically encoded voltage indicators. The proton pump Archaerhodopsin-3 (Arch), an optogenetic tool commonly used for neuronal inhibition, has been shown to emit vo... |
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Expression of endoplasmic reticulum stress markers GRP78 and CHOP induced by oxidative stress in blue light-mediated damage of A2E-containing retinal pigment epithelium cells.
Ophthalmic Res. 52(4) , 224-33, (2014) Age-related lipofuscin N-retinylidene-N-retinylethanolamine (A2E) accumulated in human retinal pigment epithelium (RPE) cells confers susceptibility to blue light-mediated damage, which represents one pathogenesis of age-related macular degeneration. This stu... |
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The Use of Liprotides To Stabilize and Transport Hydrophobic Molecules.
Biochemistry 54 , 4815-23, (2015) Recently, it has been shown that different complexes consisting of protein and fatty acids, which we call liprotides, have common functional and structural features. Liprotides can transfer their fatty acid content to membranes, highlighting the potential to ... |
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Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols.
Food Chem. Toxicol. 74 , 216-24, (2015) Blue light induced oxidative damage and ER stress are related to the pathogenesis of age-related macular degeneration (AMD). However, the mechanism of blue light-induced damage remained obscure. The objective of this work is to assess the photooxidative damag... |
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The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling.
Sci. Signal. 8 , rs8, (2015) Blastocladiomycota fungi form motile zoospores that are guided by sensory photoreceptors to areas of optimal light conditions. We showed that the microbial rhodopsin of Blastocladiella emersonii is a rhodopsin-guanylyl cyclase (RhGC), a member of a previously... |
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Cardiac Optogenetics: Enhancement by All-trans-Retinal.
Sci. Rep. 5 , 16542, (2015) All-trans-Retinal (ATR) is a photosensitizer, serving as the chromophore for depolarizing and hyperpolarizing light-sensitive ion channels and pumps (opsins), recently employed as fast optical actuators. In mammalian optogenetic applications (in brain and hea... |
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Channelrhodopsin unchained: structure and mechanism of a light-gated cation channel.
Biochim. Biophys. Acta 1837(5) , 626-42, (2014) The new and vibrant field of optogenetics was founded by the seminal discovery of channelrhodopsin, the first light-gated cation channel. Despite the numerous applications that have revolutionised neurophysiology, the functional mechanism is far from understo... |