DL-O-Tyrosine
DL-O-Tyrosine structure
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Common Name | DL-O-Tyrosine | ||
|---|---|---|---|---|
| CAS Number | 2370-61-8 | Molecular Weight | 181.18900 | |
| Density | 1.333g/cm3 | Boiling Point | 369ºC at 760mmHg | |
| Molecular Formula | C9H11NO3 | Melting Point | 260ºC | |
| MSDS | Chinese USA | Flash Point | 177ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Ion-pairing reversed-phase liquid chromatography fractionation in combination with isotope labeling reversed-phase liquid chromatography–mass spectrometry for comprehensive metabolome profiling
J. Chromatogr. A. 1218(23) , 3689-94, (2011) We report a novel two-dimensional (2D) separation strategy aimed at improving the detectability of liquid chromatography mass spectrometry (LC–MS) for metabolome analysis. It is based on the use of ion-pairing (IP) reversed-phase (RP) LC as the first dimensio... |
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Concomitant tumor resistance: the role of tyrosine isomers in the mechanisms of metastases control.
Cancer Res. 72(5) , 1043-50, (2012) Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-dependent processes mediate CR in hosts bearing immunogenic ... |
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Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.
J. Biol. Chem. 274(49) , 34621-8, (1999) Oxidative stress is implicated in the death of dopaminergic neurons in Parkinson's disease and in the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP) model of Parkinson's disease. Oxidative species that might mediate this damage include hydroxyl radical,... |
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Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats.
Am. J. Physiol. 274(2 Pt 2) , R453-61, (1998) Many lines of evidence implicate oxidative damage in aging. Possible pathways include reactions that modify aromatic amino acid residues on proteins. o-Tyrosine is a stable marker for oxidation of protein-bound phenylalanine by hydroxyl radical, whereas 3-nit... |
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Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.
J. Clin. Endocrinol. Metab. 86(6) , 2899-902, (2001) ABSTRACT Since glucose intake acutely increases reactive oxygen species (ROS) generation by polymorphonuclear leucocytes (PMN) and mononuclear cells (MNC), we have now investigated whether a fast over a period of 48h reduces ROS generation by these cells. Eig... |
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Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: evidence for hydroxyl radical production.
Kidney Int. 68(5) , 2281-7, (2005) Phenylalanine is converted to para- and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal ... |
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Comparison of low-flow cardiopulmonary bypass and circulatory arrest on brain oxygen and metabolism.
Ann. Thorac. Surg. 77(6) , 2138-43, (2004) In the neonatal brain we measured oxygen (Bo(2)), extracellular striatal dopamine (DA), and striatal tissue levels of ortho-tyrosine (o-tyr) during low-flow cardiopulmonary bypass (LFCPB) or deep hypothermic circulatory arrest (DHCA) and the post-bypass recov... |
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Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance.
Cancer Res. 71(22) , 7113-24, (2011) Concomitant tumor resistance (CR) is a phenomenon originally described in 1906 in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although recent studies have indicated that T-cell-dependent processes mediate ... |
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Effect of catecholamines on activity of Na(+), K(+)-ATPase in neonatal piglet brain during posthypoxic reoxygenation.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 132(1) , 139-45, (2002) The present study examined the possible role of dopamine on the response of Na(+), K(+)-ATPase activity in the striatum of newborn piglets to 1 h of bilateral carotid ligation with hemorrhage and 2 h of recovery. Newborn piglets, 2-4 days of age and with and ... |
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Proteins containing oxidized amino acids induce apoptosis in human monocytes.
Biochem. J. 435(1) , 207-16, (2011) Cellular deposits of oxidized and aggregated proteins are hallmarks of a variety of age-related disorders, but whether such proteins contribute to pathology is not well understood. We previously reported that oxidized proteins form lipofuscin/ceroid-like bodi... |