(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol
(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol structure
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Common Name | (S)-(+)-1,2,3,4-Tetrahydro-1-naphthol | ||
|---|---|---|---|---|
| CAS Number | 53732-47-1 | Molecular Weight | 148.202 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 254.8±0.0 °C at 760 mmHg | |
| Molecular Formula | C10H12O | Melting Point | 37-39ºC | |
| MSDS | Chinese USA | Flash Point | 99.9±11.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17.
J. Med. Chem. 49 , 1818-27, (2006) A set of 28 enantiomers comprising rigid and flexible secondary alcohols was synthesized by the asymmetric Corey-Bakshi-Shibata reduction. The enantiomerically pure alcohols were subjected to enzymatic glucuronidation assays employing the human UDP-glucuronos... |
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Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.
Bioorg. Med. Chem. Lett. 20 , 5274-6, (2010) A comparison of the structures and kinetic properties of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) and its mutant enzymes (Leu308Val and Leu308Ala) indicates that Leu308 is a selectivity determinant for substrate binding. While the Leu308Val mutatio... |
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