7-Chloro-4-quinolinamine
7-Chloro-4-quinolinamine structure
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Common Name | 7-Chloro-4-quinolinamine | ||
|---|---|---|---|---|
| CAS Number | 1198-40-9 | Molecular Weight | 178.618 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 366.8±27.0 °C at 760 mmHg | |
| Molecular Formula | C9H7ClN2 | Melting Point | 96-97°C | |
| MSDS | Chinese USA | Flash Point | 175.7±23.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.
J. Med. Chem. 51(7) , 1995-8, (2008) Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four different strains of P. falciparum. Many of the compounds tested s... |
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New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.
J. Med. Chem. 51(19) , 6216-9, (2008) The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalarial activities, with IC90 values for the Plasmodium falciparu... |
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An ELISA test for detecting chloroquine in urine.
Trans. R. Soc. Trop. Med. Hyg. 82(2) , 216-20, (1988) Two ELISA tests for detecting chloroquine in urine have been developed using polyclonal and monoclonal antibodies which react with the 7-chloro-4-amino-quinoline part of the chloroquine molecule and thus recognize chloroquine, its metabolites, and amodiaquine... |
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Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline.
Bioorg. Med. Chem. 20(19) , 5980-5, (2012) Recently the N-(-)-lupinyl-derivative of 7-chloro-4-aminoquinoline ((-)-AM-1; 7-chloro-4-{N-[(1S,9aR)(octahydro-2H-quinolizin-1-yl)methyl]amino}quinoline) showed potent in vitro and in vivo activity against both Chloroquine susceptible and resistant strains o... |
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Chloroquine metabolism in man: urinary excretion of 7-chloro-4-hydroxyquinoline and 7-chloro-4-aminoquinoline metabolites.
J. Chromatogr. A. 345(1) , 209-14, (1985)
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Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines.
Bioorg. Med. Chem. 18(18) , 6625-33, (2010) A set of nine new arylpyrrolyl derivatives of 7-chloro-4-aminoquinoline, characterized by different substituents on the phenyl ring or different distance between the pyrrolic nitrogen and the 4-aminoquinoline, has been synthesized and tested for their activit... |
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Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline.
Bioorg. Med. Chem. 20(19) , 5965-79, (2012) With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4-aminoquinoline and 7-chloro-N-(heteroaryl)-4-aminoquinoline was synthesized a... |
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Synthesis and antimalarial activity study of some new Mannich bases of 7-chloro-4-aminoquinoline.
Med. Chem. 9(3) , 379-83, (2013) New derivatives of 7-chloro-4-aminoquinoline Mannich base were prepared by selectively modifying the aliphatic diethyl amino function of isoquine with different aliphatic/aromatic heterocyclic primary amino moieties at Mannich side chain. The synthesized comp... |